Racial differences in the pathophysiology of atherothrombosis are poorly understood. We
explored the function and transcriptome of platelets in healthy black (n= 70) and white (n …

Importance Multiple studies have found an increased prevalence, younger age at onset, and
more severe course of glaucoma in people of African descent, but these findings are based …

Recent multi-dimensional approaches to the study of complex disease have revealed
powerful insights into how genetic and epigenetic factors may underlie their …

Systemic lupus erythematosus (SLE, MIM152700) is an autoimmune disease characterized
by self-reactive antibodies resulting in systemic inflammation and organ failure. TNFAIP3 …

Previous genetic studies have suggested a history of sub-Saharan African gene flow into
some West Eurasian populations after the initial dispersal out of Africa that occurred at least …

For people living in a typical hunter-gatherer population, sodium is scarce, and hypertension
is rare. 15 They are in a critical sodium balance, and any minor defect in sodium …

The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

Here we integrate the de novo assembly of an Asian and an African genome with the NCBI
reference human genome, as a step toward constructing the human pan-genome. We …

Although a few hundred single nucleotide polymorphisms (SNPs) suffice to infer close
familial relationships, high density genome-wide SNP data make possible the inference of …

Background Africa is the origin of modern humans within the past 300 thousand years. To
infer the complex demographic history of African populations and adaptation to diverse …