Pathophysiology of atherosclerosis

S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Hypertension related to obesity: pathogenesis, characteristics and factors for control

P El Meouchy, M Wahoud, S Allam, R Chedid… - International journal of …, 2022 - mdpi.com
The World Health Organization (WHO) refers to obesity as abnormal or excessive fat
accumulation that presents a health risk. Obesity was first designated as a disease in 2012 …

[HTML][HTML] microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis

F Ahangari, NL Price, S Malik, M Chioccioli… - JCI insight, 2023 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. Recent
findings have shown a marked metabolic reprogramming associated with changes in …

Nonalcoholic fatty liver disease (NAFLD): pathogenesis and noninvasive diagnosis

V Dorairaj, SA Sulaiman, N Abu, NA Abdul Murad - Biomedicines, 2021 - mdpi.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) or metabolic associated
fatty liver disease (MAFLD), as it is now known, has gradually increased. NAFLD is a …

Targeting and delivery of microRNA-targeting antisense oligonucleotides in cardiovascular diseases

G Saenz-Pipaon, DA Dichek - Atherosclerosis, 2023 - Elsevier
Discovered three decades ago, microRNAs (miRNAs) are now recognized as key players in
the pathophysiology of multiple human diseases, including those affecting the …

Boosting Cholesterol Efflux from Foam Cells by Sequential Administration of rHDL to Deliver MicroRNA and to Remove Cholesterol in a Triple‐Cell 2D Atherosclerosis …

S Jebari‐Benslaiman, KB Uribe, A Benito‐Vicente… - Small, 2022 - Wiley Online Library
Cardiovascular disease, the leading cause of mortality worldwide, is primarily caused by
atherosclerosis, which is characterized by lipid and inflammatory cell accumulation in blood …

Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets

CL Galindo, S Khan, X Zhang, YS Yeh… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Lipid-laden foam cells within atherosclerotic plaques are key players in all
phases of lesion development including its progression, necrotic core formation, fibrous cap …

A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis

M Khalifeh, RD Santos, RK Oskuee, A Badiee… - Progress in lipid …, 2023 - Elsevier
Atherosclerotic cardiovascular disease (ASCVD) is one of the major leading global causes
of death. Genetic and epidemiological studies strongly support the causal association …

miR‐33a Expression Attenuates ABCA1‐Dependent Cholesterol Efflux and Promotes Macrophage‐Like Cell Transdifferentiation in Cultured Vascular Smooth Muscle …

IC Esobi, O Oladosu, J Echesabal-Chen… - Journal of …, 2023 - Wiley Online Library
Recent evidence suggests that the majority of cholesterol‐laden cells found in
atherosclerotic lesions are vascular smooth muscle cells (VSMC) that have …

Current data and new insights into the genetic factors of atherogenic dyslipidemia associated with metabolic syndrome

LI Butnariu, EV Gorduza, E Țarcă, MC Pânzaru… - Diagnostics, 2023 - mdpi.com
Atherogenic dyslipidemia plays a critical role in the development of metabolic syndrome
(MetS), being one of its major components, along with central obesity, insulin resistance …