Bioactivity-guided synthesis accelerates the discovery of 3-(iso) quinolinyl-4-chromenones as potent fungicide candidates

W Wang, S Zhang, J Wang, F Wu… - Journal of Agricultural …, 2020 - ACS Publications
Fungal infections could cause tremendous decreases in crop yield and quality. Natural
products, including flavonoids and (iso) quinolines, have always been an important source …

The application of Sn (IV) Cl2 and In (III) Cl porphyrin-dyed TiO2 nanofibers in photodynamic antimicrobial chemotherapy for bacterial inactivation in water

K Hlabangwane, R Matshitse, M Managa… - Photodiagnosis and …, 2023 - Elsevier
Abstract The World Health Organization has reported that antimicrobial resistance is one of
the top 10 health threats that humanity faces today. Due to this, alternative therapies to the …

Antifungal activity of 3,3'-dimethoxycurcumin (DMC) against dermatophytes and Candida species

VC Pattini, CR Polaquini, TH Lemes… - Letters in Applied …, 2024 - academic.oup.com
Dermatomycosis is an infection with global impacts caused especially by dermatophytes
and Candida species. Current antifungal therapies involve drugs that face fungal resistance …

Novel Flavonol Derivatives Containing 1, 3, 4-Thiadiazole as Potential Antifungal Agents: Design, Synthesis, and Biological Evaluation

Y Zhou, C Gong, Z Sun, W Zeng, K Meng, Y An… - ACS …, 2024 - ACS Publications
In order to discover novel compounds with excellent agricultural activities, novel flavonol
derivatives containing 1, 3, 4-thiadiazole were synthesized and evaluated for their antifungal …

Synergistic activity between conventional antifungals and chalcone-derived compound against dermatophyte fungi and Candida spp.

T Maschio-Lima, TH Lemes, MDR Marques… - International …, 2024 - Springer
The scarce antifungal arsenal, changes in the susceptibility profile of fungal agents, and lack
of adherence to treatment have contributed to the increase of cases of dermatomycoses. In …

Testing of Anti-EMT, Anti-Inflammatory and Antibacterial Activities of 2′, 4′-Dimethoxychalcone

P Zhao, M Xu, K Gong, K Lu, C Ruan, X Yu, J Zhu… - Pharmaceuticals, 2024 - mdpi.com
Chalcone (1, 3-diaryl-2-propen-1-one) is an α, β-unsaturated ketone that serves as an active
constituent or precursor of numerous natural substances, exhibiting a broad spectrum of …

Evaluation of efficacy of new chalcone-based endodontic irrigant against dual biofilm Enterococcus faecalis and Candida albicans: a study in vitro

J Graciani, PL Rosalen… - Odontology, 2023 - Springer
The aim of this research was to develop a chalcone-based endodontic irrigant for cleaning
and disinfecting the root canal. Minimal inhibitory concentration (MIC) experiments in C …

Curcumin-cinnamaldehyde hybrids as antiproliferative agents against women's cancer cells

DB Anselmo, CR Polaquini, BC Marques… - Medicinal Chemistry …, 2021 - Springer
Curcumin and cinnamaldehyde are natural products whose antineoplastic activity has been
well explored in biological evaluations. However, their poor chemical stability under …

Design synthesis and photophysical properties of a novel antitumor fluorescence agents

J Cao, G Lian, X Qi, G Jin - Journal of Molecular Structure, 2021 - Elsevier
Four novel fluorescent antitumor compounds were synthesized in three steps. In this paper,
boron fluoride was introduced into the side bond of pyrimidine ring through a simple …