[HTML][HTML] Mechanisms leading to gut dysbiosis in COVID-19: current evidence and uncertainties based on adverse outcome pathways
LA Clerbaux, J Filipovska, A Muñoz, M Petrillo… - Journal of Clinical …, 2022 - mdpi.com
Alteration in gut microbiota has been associated with COVID-19. However, the underlying
mechanisms remain poorly understood. Here, we outlined three potential interconnected …
mechanisms remain poorly understood. Here, we outlined three potential interconnected …
Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA–protein condensates
Y Chen, X Lei, Z Jiang, F Humphries… - Proceedings of the …, 2023 - National Acad Sciences
A detailed understanding of the innate immune mechanisms involved in restricting SARS-
CoV-2 infection and how the virus disrupts these processes could reveal new strategies to …
CoV-2 infection and how the virus disrupts these processes could reveal new strategies to …
[HTML][HTML] Neutrophil extracellular traps, local IL-8 expression, and cytotoxic T-lymphocyte response in the lungs of patients with fatal COVID-19
I Melero, M Villalba-Esparza, B Recalde-Zamacona… - Chest, 2022 - Elsevier
Background Excessive inflammation is pathogenic in the pneumonitis associated with
severe COVID-19. Neutrophils are among the most abundantly present leukocytes in the …
severe COVID-19. Neutrophils are among the most abundantly present leukocytes in the …
[HTML][HTML] The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases
X Shi, H Zhou, J Wei, W Mo, Q Li, X Lv - Redox Biology, 2022 - Elsevier
Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …
[HTML][HTML] Potential for early noninvasive COVID-19 detection using electronic-nose technologies and disease-specific VOC metabolic biomarkers
AD Wilson, LB Forse - Sensors, 2023 - mdpi.com
The established efficacy of electronic volatile organic compound (VOC) detection
technologies as diagnostic tools for noninvasive early detection of COVID-19 and related …
technologies as diagnostic tools for noninvasive early detection of COVID-19 and related …
Low prevalence of interferon α autoantibodies in people experiencing symptoms of post–coronavirus disease 2019 (COVID-19) conditions, or long COVID
MJ Peluso, A Mitchell, CY Wang… - The Journal of …, 2023 - academic.oup.com
Interferon (IFN)–specific autoantibodies have been implicated in severe coronavirus disease
2019 (COVID-19) and have been proposed as a potential driver of the persistent symptoms …
2019 (COVID-19) and have been proposed as a potential driver of the persistent symptoms …
Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post‐acute sequelae of COVID‐19
C Schultheiß, E Willscher, L Paschold… - Journal of Medical …, 2023 - Wiley Online Library
Post‐acute sequelae of COVID‐19 (PASC) are long‐term consequences of SARS‐CoV‐2
infection that can substantially impair the quality of life. Underlying mechanisms ranging …
infection that can substantially impair the quality of life. Underlying mechanisms ranging …
Lots of long COVID treatment leads, but few are proven
L Shaffer - Proceedings of the National Academy of …, 2022 - National Acad Sciences
As the current crisis phase of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) pandemic winds down—and the world nervously awaits potentially dangerous new …
CoV-2) pandemic winds down—and the world nervously awaits potentially dangerous new …
[HTML][HTML] Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus
B Li, R Ma, L Chen, C Zhou, YX Zhang, X Wang… - Nature …, 2023 - nature.com
Enveloped viruses encased within a lipid bilayer membrane are highly contagious and can
cause many infectious diseases like influenza and COVID-19, thus calling for effective …
cause many infectious diseases like influenza and COVID-19, thus calling for effective …
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19
The relationship between diabetes and coronavirus disease 2019 (COVID-19) is
bidirectional: Although individuals with diabetes and high blood glucose (hyperglycemia) …
bidirectional: Although individuals with diabetes and high blood glucose (hyperglycemia) …