Kidney and epigenetic mechanisms of salt-sensitive hypertension

W Kawarazaki, T Fujita - Nature Reviews Nephrology, 2021 - nature.com
Dietary salt intake increases blood pressure (BP) but the salt sensitivity of BP differs
between individuals. The interplay of ageing, genetics and environmental factors, including …

Polyphenols as caloric-restriction mimetics and autophagy inducers in aging research

A Yessenkyzy, T Saliev, M Zhanaliyeva, AR Masoud… - Nutrients, 2020 - mdpi.com
It has been thought that caloric restriction favors longevity and healthy aging where
autophagy plays a vital role. However, autophagy decreases during aging and that can lead …

[HTML][HTML] Novel mechanisms of salt-sensitive hypertension

L Vogt, FZ Marques, T Fujita, EJ Hoorn, AHJ Danser - Kidney International, 2023 - Elsevier
A high dietary sodium-consumption level is considered the most important lifestyle factor that
can be modified to help prevent an increase in blood pressure and the development of …

Gut-immune-kidney axis: influence of dietary protein in salt-sensitive hypertension

DL Mattson, JH Dasinger, JM Abais-Battad - Hypertension, 2022 - Am Heart Assoc
Humans with salt-sensitive hypertension demonstrate increased morbidity, increased
mortality, and renal end-organ damage when compared with normotensive subjects or those …

Sex-specific epigenetic programming in renal fibrosis and inflammation

P Kumar, HL Brooks - American Journal of Physiology …, 2023 - journals.physiology.org
The growing prevalence of hypertension, heart disease, diabetes, and obesity along with an
aging population is leading to a higher incidence of renal diseases in society. Chronic …

Dietary influences on the Dahl SS rat gut microbiota and its effects on salt‐sensitive hypertension and renal damage

JM Abais‐Battad, FL Saravia, H Lund… - Acta …, 2021 - Wiley Online Library
Aim Our previous studies have demonstrated the importance of dietary factors in the
determination of hypertension in Dahl salt‐sensitive (SS) rats. Since the gut microbiota has …

Salt sensitivity of blood pressure in Black people: the need to sort out ancestry versus epigenetic versus social determinants of its causation

F Elijovich, A Kirabo, CL Laffer - Hypertension, 2024 - Am Heart Assoc
Race is a social construct, but self-identified Black people are known to have higher
prevalence and worse outcomes of hypertension than White people. This may be partly due …

Activation of the sympathetic nervous system promotes blood pressure salt-sensitivity in C57BL6/J mice

AF Ralph, C Grenier, HM Costello, K Stewart, JR Ivy… - …, 2021 - Am Heart Assoc
Global salt intake averages> 8 g/person per day, over twice the limit advocated by the
American Heart Association. Dietary salt excess leads to hypertension, and this partly …

Recent advances in hypertension: epigenetic mechanism involved in development of salt-sensitive hypertension

T Fujita - Hypertension, 2023 - Am Heart Assoc
This review highlights recent insights into the epigenetic mechanism of salt-sensitive
hypertension from the fetus to the elderly population, mainly focusing on the DNA …

Amplification of salt-sensitive hypertension and kidney damage by immune mechanisms

DL Mattson, JH Dasinger… - American journal of …, 2021 - academic.oup.com
Humans with salt-sensitive (SS) hypertension demonstrate increased morbidity, increased
mortality, and renal end-organ damage when compared with normotensive subjects or those …