Continuous turnover of intracellular proteins is essential for the maintenance of cellular
homeostasis and for the regulation of multiple cellular functions. The first reports showing a …

Proteasomal dysfunction may play a role in neurodegenerative conditions and protein
aggregation. Overexpression in neuronal cells of α-synuclein, a molecule linked to …

During meiotic prophase in male mammals, the X and Y chromosomes are incorporated in
the XY body. This heterochromatic body is transcriptionally silenced and marked by …

YOD1 is a highly conserved deubiquitinating enzyme of the ovarian tumor (otubain) family,
whose function has yet to be assigned in mammalian cells. YOD1 is a constituent of a …

Nuclear retinoic acid receptors (RARs) are transcriptional regulators controlling the
expression of specific subsets of genes in a ligand-dependent manner. The basic …

The mechanism of cell death in prion disease is unknown but is associated with the
production of a misfolded conformer of the prion protein. We report that disease-associated …

The 26S proteasome is a multisubunit complex responsible for degradation of ubiquitinated
substrates, which plays a critical role in regulating various biological processes. To fully …

An unusual deubiquitinating (DUB) activity exists in HeLa cell extracts that is highly specific
for cleaving K63‐linked but not K48‐linked polyubiquitin chains. The activity is insensitive to …

We developed an integrated proteomic approach to decipher in vivo protein-protein
interactions and applied this strategy to globally map the 26 S proteasome interaction …

The adipose-specific protein adiponectin has been recently discovered to improve insulin
sensitivity. Angiotensin type-1 receptor (AT1R) blockers (ARBs) reduce the incidence of type …