The success of Mycobacterium tuberculosis (Mtb) as a human pathogen relies on its ability
to resist eradication by the immune system. The identification of mechanisms that enable …

Emerging data reveal that besides degrading proteins tagged with ubiquitin, the proteasome
plays a more varied and decisive role in cellular regulation than previously imagined. In this …

During the past decade, it has become apparent that a set of ostensibly unrelated
neurodegenerative diseases, including Parkinson's disease and Huntington's disease …

Linkage-specific polyubiquitin recognition is thought to make possible the diverse set of
functional outcomes associated with ubiquitination. Thus far, mechanistic insight into this …

We determined composition and relative roles of deubiquitylating proteins associated with
the 26S proteasome in mammalian cells. Three deubiquitylating activities were associated …

Increasing genetic, pathological, and experimental evidence suggest that
neurodegeneration in both familial and sporadic forms of Parkinson's disease (PD) may be …

The factors required for the delivery of RNA polymerase II to class II promoters using naked
DNA were all identified by 1998, yet their exact mechanisms of action were not fully …

To ensure correct function, mitochondria have developed several mechanisms of protein
quality control (QC). Protein homeostasis highly relies on chaperones and proteases to …

The centrosome is an indispensable component of the cell-cycle machinery of eukaryotic
cells, and the perturbation of core centrosomal or centrosome-associated proteins is linked …

Terpenoids represent a large and diverse class of naturally occurring compounds found in a
variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are …