[HTML][HTML] Systemic inflammation index, disease severity, and mortality in patients with COVID-19: a systematic review and meta-analysis

AA Mangoni, A Zinellu - Frontiers in Immunology, 2023 - frontiersin.org
Introduction An excessive systemic pro-inflammatory state increases the risk of severe
disease and mortality in patients with coronavirus disease 2019 (COVID-19). However, there …

[HTML][HTML] Regulated Arginine Metabolism in Immunopathogenesis of a Wide Range of Diseases: Is There a Way to Pass between Scylla and Charybdis?

EA Starikova, AA Rubinstein, JT Mammedova… - Current Issues in …, 2023 - mdpi.com
More than a century has passed since arginine was discovered, but the metabolism of the
amino acid never ceases to amaze researchers. Being a conditionally essential amino acid …

Viral target and metabolism‐based rationale for combined use of recently authorized small molecule COVID‐19 medicines: Molnupiravir, nirmatrelvir, and remdesivir

D Yan, B Yan - Fundamental & Clinical Pharmacology, 2023 - Wiley Online Library
The COVID‐19 pandemic remains a major health concern worldwide, and SARS‐CoV‐2 is
continuously evolving. There is an urgent need to identify new antiviral drugs and develop …

[HTML][HTML] Stem cell-based therapy for COVID-19

X Chen, B Liu, C Li, Y Wang, S Geng, X Du… - International …, 2023 - Elsevier
Abstract While The World Health Organization (WHO) has announced that COVID-19 is no
longer a public health emergency of international concern (PHEIC), the risk of reinfection …

[HTML][HTML] Aggregate Index of Systemic Inflammation (AISI), Disease Severity, and Mortality in COVID-19: A Systematic Review and Meta-Analysis

A Zinellu, P Paliogiannis, AA Mangoni - Journal of Clinical Medicine, 2023 - mdpi.com
Combined indices of different haematological cell types appear to be particularly promising
for investigating the link between systemic inflammation and coronavirus disease 2019 …

[HTML][HTML] Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing

Y Liu, C Xiang, Z Que, C Li, W Wang, L Yin… - Frontiers in …, 2023 - frontiersin.org
Neutrophils play a critical role in the immune response to infection and tissue injury.
However, recent studies have shown that neutrophils are a heterogeneous population with …

[HTML][HTML] Taming the SARS-CoV-2-mediated proinflammatory response with BromAc®

GM Ferreira, FA Clarindo, ÁL Ribeiro… - Frontiers in …, 2023 - frontiersin.org
Introduction In the present study, the impact of BromAc®, a specific combination of
bromelain and acetylcysteine, on the SARS-CoV-2-specific inflammatory response was …

Immune checkpoint inhibitors and SARS-CoV2 infection

S Abdolmohammadi-Vahid, B Baradaran… - International …, 2024 - Elsevier
Infection with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) triggers
coronavirus disease 2019 (COVID-19), which predominantly targets the respiratory tract …

Beyond the acute illness: Exploring long COVID and its impact on multiple organ systems

N Bhattacharjee, P Sarkar, T Sarkar - Physiology International, 2023 - akjournals.com
Unprecedented worldwide health catastrophe due to the COVID-19 pandemic has ended up
resulting in high morbidity and mortality rates. Even though many people recover from acute …

[HTML][HTML] Gut microbiota composition is associated with disease severity and host immune responses in COVID-19

R Fan, S Liu, N Sun, Y Yang, X Deng, B Hu… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Background Human gut microbiota play a crucial role in the immune response of the host to
respiratory viral infection. However, evidence regarding the association between the gut …