D Basu, VP Chavda, AA Mehta - Current Research in Pharmacology and …, 2022 - Elsevier
Since its inception in late December 2020 in China, novel coronavirus has affected the global socio-economic aspect. Currently, the world is seeking safe and effective treatment …
H Jing, X Wu, M Xiang, L Liu, VA Novakovic… - Frontiers in …, 2022 - frontiersin.org
COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …
Highlights•Repurposing existing drugs for new diseases is cost effective and time saving.•In silico methods are crucial for rapid drug screening in the early stages.•Machine learning …
J Yin, C Li, C Ye, Z Ruan, Y Liang, Y Li, J Wu… - Computational and …, 2022 - Elsevier
Abstract Since Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was identified in late 2019, the coronavirus disease 2019 (COVID-19) pandemic has challenged …
S Ambike, CC Cheng, M Feuerherd… - Nucleic Acids …, 2022 - academic.oup.com
A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS- CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …
The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had devastating effects on the global health and economic system. The cellular and molecular …
MC Chiu, C Li, X Liu, Y Yu, J Huang, Z Wan, D Xiao… - Cell discovery, 2022 - nature.com
The airways and alveoli of the human respiratory tract are lined by two distinct types of epithelium, which are the primary targets of respiratory viruses. We previously established …
EM Parzych, J Du, AR Ali, K Schultheis, D Frase… - Nature …, 2022 - nature.com
Monoclonal antibody therapy has played an important role against SARS-CoV-2. Strategies to deliver functional, antibody-based therapeutics with improved in vivo durability are …
Abstract BioNTech/Pfizer's Comirnaty and Moderna's SpikeVax vaccines consist in mRNA encapsulated in lipid nanoparticles (LNPs). The modularity of the delivery platform and the …