Impaired immune function has been implicated in the declining health and higher incidence
of cancer in the elderly. However, age-related changes to immunity are not completely …

Immune checkpoint inhibitors (ICIs) are based on the understanding that there are
multilayered checks and balances which can be manipulated to unleash already existing …

Hypoxia induces protective autophagy in glioblastoma cells and new therapeutic avenues
that target this process may improve the outcome for glioblastoma patients. Recent studies …

A chronic low-grade inflammation is one of the hallmarks of the aging process. This
gradually augmenting inflammatory state has been termed inflammaging. Inflammaging is …

Improvements in understanding cancer immunopathogenesis have now led to
unprecedented successes in immunotherapy to treat numerous cancers. Although aging is …

Nanosafety assessment has experienced an intense era of research during the past
decades driven by a vivid interest of regulators, industry, and society. Toxicological assays …

The advent of immune checkpoint inhibitors (ICIs) has changed the landscape of cancer
treatment. Older adults represent the majority of cancer patients; however, direct data …

Vaccination, being able to prevent millions of cases of infectious diseases around the world
every year, is the most effective medical intervention ever introduced. However …

Myeloid-derived suppressor cells (MDSCs) are innate immune cells characterised by their
potential to control T-cell responses and to dampen inflammation. While the role of MDSCs …

Ageing has pronounced effects on the immune system, including on innate immune cells.
Whilst most studies suggest that total numbers of different innate immune cell populations do …