Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis

E Di Maria, A Latini, P Borgiani, G Novelli - Human genomics, 2020 - Springer
The COVID-19 pandemic has strengthened the interest in the biological mechanisms
underlying the complex interplay between infectious agents and the human host. The …

Pharmacogenomics of COVID-19 therapies

T Takahashi, JA Luzum, MR Nicol… - NPJ genomic …, 2020 - nature.com
A new global pandemic of coronavirus disease 2019 (COVID-19) has resulted in high
mortality and morbidity. Currently numerous drugs are under expedited investigations …

Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs

OA Badary - The pharmacogenomics journal, 2021 - nature.com
The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …

Cell-free DNA in rheumatoid arthritis

T Hashimoto, K Yoshida, A Hashiramoto… - International journal of …, 2021 - mdpi.com
Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream
following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is …

Genetic polymorphisms associated with rheumatoid arthritis development and antirheumatic therapy response

DS Mikhaylenko, MV Nemtsova, IV Bure… - International journal of …, 2020 - mdpi.com
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy worldwide. Possible
manifestations of RA can be represented by a wide variability of symptoms, clinical forms …

Pharmacogenetics and precision medicine approaches for the improvement of COVID-19 therapies

M Biswas, N Sawajan, T Rungrotmongkol… - Frontiers in …, 2022 - frontiersin.org
Many drugs are being administered to tackle coronavirus disease 2019 (COVID-19)
pandemic situations without establishing clinical effectiveness or tailoring safety. A …

Host genetics at the intersection of autoimmunity and COVID-19: a potential key for heterogeneous COVID-19 severity

T Karaderi, H Bareke, I Kunter, A Seytanoglu… - Frontiers in …, 2020 - frontiersin.org
COVID-19 presentation is very heterogeneous across cases, and host factors are at the
forefront for the variables affecting the disease manifestation. The immune system has …

Pharmacogenomics of monoclonal antibodies for the treatment of rheumatoid arthritis

SH Lim, K Kim, CI Choi - Journal of Personalized Medicine, 2022 - mdpi.com
Precision medicine refers to a highly individualized and personalized approach to patient
care. Pharmacogenomics is the study of how an individual's genomic profile affects their …

FCGR2A/FCGR3A gene polymorphisms and clinical variables as predictors of response to tocilizumab and rituximab in patients with rheumatoid arthritis

A Jiménez Morales… - The Journal of …, 2019 - Wiley Online Library
We evaluated the influence of clinical, biochemical, and genetic factors on response in 142
patients diagnosed with rheumatoid arthritis, of whom 87 patients were treated with …

Will the use of pharmacogenetics improve treatment efficiency in COVID-19?

B Franczyk, J Rysz, J Miłoński, T Konecki… - Pharmaceuticals, 2022 - mdpi.com
The COVID-19 pandemic is associated with a global health crisis and the greatest challenge
for scientists and doctors. The virus causes severe acute respiratory syndrome with an …