Executive summary 50 years after a noble but flawed attempt to eradicate malaria in the mid-
20th century, the global malaria community is once again seriously considering eradication …

In the 21st century, an array of microbiological and molecular allow antigens for new
vaccines to be specifically identified, designed, produced and delivered with the aim of …

Investigation of the diversity of malaria parasite antigens can help prioritize and validate
them as vaccine candidates and identify the most common variants for inclusion in vaccine …

Vaccines have typically been prepared using whole organisms. These are normally either
attenuated bacteria or viruses that are live but have been altered to reduce their virulence, or …

Malaria parasites undergo a complex life cycle between their hosts and vectors. During this
cycle the parasites invade different types of cells, migrate across barriers, and transfer from …

Outbreaks and the rapid transmission of viruses, such as coronaviruses and influenza
viruses, are serious threats to human health. A major challenge in combating infectious …

Genome graphs allow very general representations of genetic variation; depending on the
model and implementation, variation at different length-scales (single nucleotide …

Prospects for malaria eradication will be greatly enhanced by an effective vaccine, but
parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent …

Abstract Background Plasmodium falciparum (Pf) whole-organism sporozoite vaccines have
been shown to provide significant protection against controlled human malaria infection …

Introduction The human malaria parasite, Plasmodium vivax, is proving more difficult to
control and eliminate than Plasmodium falciparum in areas of co-transmission. Comparisons …