[HTML][HTML] 15 years of GWAS discovery: realizing the promise

A Abdellaoui, L Yengo, KJH Verweij… - The American Journal of …, 2023 - cell.com
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

Discovery and implications of polygenicity of common diseases

PM Visscher, L Yengo, NJ Cox, NR Wray - Science, 2021 - science.org
The sequencing of the human genome has allowed the study of the genetic architecture of
common diseases: the number of genomic variants that contribute to risk of disease and …

LDpred2: better, faster, stronger

F Privé, J Arbel, BJ Vilhjálmsson - Bioinformatics, 2020 - academic.oup.com
Motivation Polygenic scores have become a central tool in human genetics research.
LDpred is a popular method for deriving polygenic scores based on summary statistics and …

[HTML][HTML] Mechanisms of neuroplasticity linking early adversity to depression: developmental considerations

TC Ho, LS King - Translational psychiatry, 2021 - nature.com
Early exposure to psychosocial adversity is among the most potent predictors of depression.
Because depression commonly emerges prior to adulthood, we must consider the …

Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology

CH Burt - Behavioral and brain sciences, 2023 - cambridge.org
The sociogenomics revolution is upon us, we are told. Whether revolutionary or not,
sociogenomics is poised to flourish given the ease of incorporating polygenic scores (or …

Cultural evolution of genetic heritability

R Uchiyama, R Spicer… - Behavioral and Brain …, 2022 - cambridge.org
Behavioral genetics and cultural evolution have both revolutionized our understanding of
human behavior–largely independent of each other. Here, we reconcile these two fields …

[HTML][HTML] The body keeps the score: The neurobiological profile of traumatized adolescents

D Laricchiuta, A Panuccio, E Picerni, D Biondo… - … & biobehavioral reviews, 2023 - Elsevier
Trauma-related disorders are debilitating psychiatric conditions that affect people who have
directly or indirectly witnessed adversities. Experiencing multiple types of traumas appears …

Toward a better understanding of the causal effects of role demands on work–family conflict: A genetic modeling approach.

TD Allen, J Regina, BM Wiernik… - Journal of Applied …, 2023 - psycnet.apa.org
Over the past several decades, there has been considerable interest in the theoretical
causes of work–family conflict (WFC). Most studies have focused on situational …

[PDF][PDF] Interactions between poly genic scores and envi ron ments: Methodological and con cep tual chal lenges

BW Domingue, S Trejo… - Sociologi-cal …, 2020 - sociologicalscience.com
Interest in the study of gene–environment interaction has recently grown due to the sudden
availability of molecular genetic data—in particular, polygenic scores—in many long-running …

Evaluating the continued integration of genetics into medical sociology

JD Boardman, JM Fletcher - Journal of Health and Social …, 2021 - journals.sagepub.com
The 2010 special issue of Journal of Health and Social Behavior, titled “Fifty Years of
Medical Sociology,” defined the contours of the medical sociological perspective. We use …