Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …

ADP‐ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad
functions, including roles in stress responses elicited, for example, by DNA damage and …

PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease
(PD), are characterized by progressive memory loss and motor impairment. Aging is a major …

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting up to 30% of the
general adult population. NAFLD encompasses a histological spectrum ranging from pure …

Post-translational modification of proteins with poly (ADP-ribose)(PAR) is an important
component of the DNA damage response. Four PAR synthesis inhibitors have recently been …

Obesity is a chronic and relapsing public health problem with an extensive list of associated
comorbidities. The worldwide prevalence of obesity has nearly tripled over the last five …

Adipogenesis is the process through which preadipocytes differentiate into adipocytes.
During this process, the preadipocytes cease to proliferate, begin to accumulate lipid …

Sirtuins (SIRTs), enzymes from the family of NAD+-dependent histone deacetylases, play an
important role in the functioning of the body at the cellular level and participate in many …