Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Over the past 10 years, circulating tumor cells (CTC) and circulating tumor DNA (ctDNA)
have received enormous attention as new biomarkers and subjects of translational research …

The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …

Background & Aims Intratumor molecular heterogeneity is a key feature of tumorigenesis
and is linked to treatment failure and patient prognosis. Herein, we aimed to determine what …

The advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …

During tumor progression, cancer cells come into contact with various non-tumor cell types,
but it is unclear how tumors adapt to these new environments. Here, we integrate spatially …

Understanding and predicting molecular responses in single cells upon chemical, genetic or
mechanical perturbations is a core question in biology. Obtaining single-cell measurements …

Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …

The causes of pediatric cancers' distinctiveness compared to adult-onset tumors of the same
type are not completely clear and not fully explained by their genomes. In this study, we …

Highlights•CVs have been characterized by positive safety and immunogenicity profiles but
low levels of clinical efficacy.•Novel CV strategies entail personalized formulations and …