The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning
autoimmune and infectious diseases, transplantation and cancer. While coding variation in …

Simple Summary This study explains how the application of single-cell transcriptomics can
enhance personalized cancer immunotherapy. Tumors exhibit complex and heterogeneous …

Through investigating the combined impact of the environmental exposures experienced by
an individual throughout their lifetime, exposome research provides opportunities to …

Genome-wide association studies (GWAS) have identified numerous genetic variants
associated with diseases and traits. However, the functional interpretation of these variants …

Expression quantitative trait loci (eQTLs) provide a key bridge between noncoding DNA
sequence variants and organismal traits. The effects of eQTLs can differ among tissues, cell …

Single-cell transcriptome data can provide insights into how genetic variation influences
biological processes involved in human biology and disease. However, the identification of …

Recent technological and algorithmic advances enable single-cell transcriptomic analysis
with remarkable depth and breadth. Nonetheless, a persistent challenge is the compromise …

Mapping of expression quantitative trait loci (eQTLs) and other molecular QTLs can help
characterize the modes of action of disease-associated genetic variants. However, current …

Spatial transcriptomics allows for the analysis of a cell's gene expression in the context of its
physical location. With spatial transcriptomics data, investigators often want to find genes of …

Identifying response expression quantitative trait loci (reQTLs) can help to elucidate
mechanisms of disease associations. Typically, such studies model the effect of perturbation …