15 years of GWAS discovery: realizing the promise

A Abdellaoui, L Yengo, KJH Verweij… - The American Journal of …, 2023 - cell.com
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

Tutorial: a guide to performing polygenic risk score analyses

SW Choi, TSH Mak, PF O'Reilly - Nature protocols, 2020 - nature.com
A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's
genetic liability to a trait or disease, calculated according to their genotype profile and …

Polygenic scores: prediction versus explanation

R Plomin, S Von Stumm - Molecular psychiatry, 2022 - nature.com
During the past decade, polygenic scores have become a fast-growing area of research in
the behavioural sciences. The ability to directly assess people's genetic propensities has …

Genetic variation, brain, and intelligence differences

IJ Deary, SR Cox, WD Hill - Molecular psychiatry, 2022 - nature.com
Individual differences in human intelligence, as assessed using cognitive test scores, have a
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …

Parental characteristics and offspring mental health and related outcomes: A systematic review of genetically informative literature

ES Jami, AR Hammerschlag, M Bartels… - Translational …, 2021 - nature.com
Various parental characteristics, including psychiatric disorders and parenting behaviours,
are associated with offspring mental health and related outcomes in observational studies …

More than nature and nurture, indirect genetic effects on children's academic achievement are consequences of dynastic social processes

MG Nivard, DW Belsky, KP Harden, T Baier… - Nature Human …, 2024 - nature.com
Abstract Families transmit genes and environments across generations. When parents'
genetics affect their children's environments, these two modes of inheritance can produce an …

Dissecting polygenic signals from genome-wide association studies on human behaviour

A Abdellaoui, KJH Verweij - Nature Human Behaviour, 2021 - nature.com
Genome-wide association studies on human behavioural traits are producing large amounts
of polygenic signals with significant predictive power and potentially useful biological clues …

Twin studies to GWAS: there and back again

NP Friedman, MT Banich, MC Keller - Trends in cognitive sciences, 2021 - cell.com
The field of human behavioral genetics has come full circle. It began by using twin/family
studies to estimate the relative importance of genetic and environmental influences. As large …

A cumulative risk and resilience model of dyslexia

HW Catts, Y Petscher - Journal of Learning Disabilities, 2022 - journals.sagepub.com
Considerable attention and legislation are currently focused on developmental dyslexia. A
major challenge to these efforts is how to define and operationalize dyslexia. In this article …

Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology

CH Burt - Behavioral and brain sciences, 2023 - cambridge.org
The sociogenomics revolution is upon us, we are told. Whether revolutionary or not,
sociogenomics is poised to flourish given the ease of incorporating polygenic scores (or …