[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy
S Shkunnikova, A Mijakovac, L Sironic, M Hanic… - Biotechnology …, 2023 - Elsevier
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
Human age reversal: Fact or fiction?
AA Johnson, BW English, MN Shokhirev… - Aging …, 2022 - Wiley Online Library
Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …
Insights into ageing rates comparison across tissues from recalibrating cerebellum DNA methylation clock
DNA methylation (DNAm)-based age clocks have been studied extensively as a biomarker
of human ageing and a risk factor for age-related diseases. Despite different tissues having …
of human ageing and a risk factor for age-related diseases. Despite different tissues having …
ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first‐degree relatives of type 2 diabetics
Senescence of adipose precursor cells (APC) impairs adipogenesis, contributes to the age‐
related subcutaneous adipose tissue (SAT) dysfunction, and increases risk of type 2 …
related subcutaneous adipose tissue (SAT) dysfunction, and increases risk of type 2 …
On epigenetic stochasticity, entropy and cancer risk
AE Teschendorff - … Transactions of the Royal Society B, 2024 - royalsocietypublishing.org
Epigenetic changes are known to accrue in normal cells as a result of ageing and
cumulative exposure to cancer risk factors. Increasing evidence points towards age-related …
cumulative exposure to cancer risk factors. Increasing evidence points towards age-related …
[HTML][HTML] Aging clocks based on accumulating stochastic variation
DH Meyer, B Schumacher - Nature Aging, 2024 - nature.com
Aging clocks have provided one of the most important recent breakthroughs in the biology of
aging, and may provide indicators for the effectiveness of interventions in the aging process …
aging, and may provide indicators for the effectiveness of interventions in the aging process …
Genetic loci and metabolic states associated with murine epigenetic aging
Abstract Changes in DNA methylation (DNAm) are linked to aging. Here, we profile highly
conserved CpGs in 339 predominantly female mice belonging to the BXD family for which …
conserved CpGs in 339 predominantly female mice belonging to the BXD family for which …
Accelerated aging mediates the associations of unhealthy lifestyles with cardiovascular disease, cancer, and mortality
X Li, X Cao, J Zhang, J Fu… - Journal of the …, 2024 - Wiley Online Library
Background With two well‐validated aging measures capturing mortality and morbidity risk,
this study examined whether and to what extent aging mediates the associations of …
this study examined whether and to what extent aging mediates the associations of …
Heritability of the glycan clock of biological age
Immunoglobulin G is posttranslationally modified by the addition of complex N-glycans
affecting its function and mediating inflammation at multiple levels. IgG glycome composition …
affecting its function and mediating inflammation at multiple levels. IgG glycome composition …
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume
The concept of age acceleration, the difference between biological age and chronological
age, is of growing interest, particularly with respect to age-related disorders, such as …
age, is of growing interest, particularly with respect to age-related disorders, such as …