Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease

J Baek, C He, F Afshinnia, G Michailidis… - Nature Reviews …, 2022 - nature.com
Dyslipidaemia is a hallmark of chronic kidney disease (CKD). The severity of dyslipidaemia
not only correlates with CKD stage but is also associated with CKD-associated …

Biomarkers of acute and chronic kidney disease

WR Zhang, CR Parikh - Annual review of physiology, 2019 - annualreviews.org
The current unidimensional paradigm of kidney disease detection is incompatible with the
complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has …

Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis

G Wang, M Qiu, X Xing, J Zhou, H Yao, M Li… - Science Translational …, 2022 - science.org
Lung cancer is the leading cause of cancer mortality, and early detection is key to improving
survival. However, there are no reliable blood-based tests currently available for early-stage …

Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

X Wang, S Yang, S Li, L Zhao, Y Hao, J Qin, L Zhang… - Gut, 2020 - gut.bmj.com
Objective Patients with renal failure suffer from symptoms caused by uraemic toxins,
possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is …

METLIN: a technology platform for identifying knowns and unknowns

C Guijas, JR Montenegro-Burke… - Analytical …, 2018 - ACS Publications
METLIN originated as a database to characterize known metabolites and has since
expanded into a technology platform for the identification of known and unknown …

[HTML][HTML] Pathophysiologic mechanisms and potential biomarkers in diabetic kidney disease

CY Jung, TH Yoo - Diabetes & Metabolism Journal, 2022 - synapse.koreamed.org
Although diabetic kidney disease (DKD) remains the leading cause of end-stage kidney
disease eventually requiring chronic kidney replacement therapy, the prevalence of DKD …

Metabolome changes in cerebral ischemia

TH Shin, DY Lee, S Basith, B Manavalan, MJ Paik… - Cells, 2020 - mdpi.com
Cerebral ischemia is caused by perturbations in blood flow to the brain that trigger
sequential and complex metabolic and cellular pathologies. This leads to brain tissue …

Mass spectrometry-based metabolomics in health and medical science: A systematic review

X Zhang, Q Li, J Dou - RSC advances, 2020 - pubs.rsc.org
Metabolomics is the study of the investigation of small molecules derived from cellular and
organism metabolism, which reflects the outcomes of the complex network of biochemical …

Why should we measure free 25 (OH) vitamin D?

O Tsuprykov, X Chen, CF Hocher, R Skoblo… - The Journal of steroid …, 2018 - Elsevier
Vitamin D, either in its D 2 or D 3 form, is essential for normal human development during
intrauterine life, kidney function and bone health. Vitamin D deficiency has also been linked …

[HTML][HTML] Monitoring wastewater for assessing community health: Sewage Chemical-Information Mining (SCIM)

CG Daughton - Science of The Total Environment, 2018 - Elsevier
Timely assessment of the aggregate health of small-area human populations is essential for
guiding the optimal investment of resources needed for preventing, avoiding, controlling, or …