[HTML][HTML] Host-parasite interactions during Plasmodium infection: Implications for immunotherapies
Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …
in the developing world. Multiple environmental and host and parasite factors govern the …
[HTML][HTML] A potent anti-malarial human monoclonal antibody targets circumsporozoite protein minor repeats and neutralizes sporozoites in the liver
LT Wang, LS Pereira, Y Flores-Garcia, J O'Connor… - Immunity, 2020 - cell.com
Discovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating their …
Investigating parasites in three dimensions: trends in volume microscopy
To best understand parasite, host, and vector morphologies, host–parasite interactions, and
to develop new drug and vaccine targets, structural data should, ideally, be obtained and …
to develop new drug and vaccine targets, structural data should, ideally, be obtained and …
[HTML][HTML] A candidate antibody drug for prevention of malaria
KL Williams, S Guerrero, Y Flores-Garcia, D Kim… - Nature medicine, 2024 - nature.com
Over 75% of malaria-attributable deaths occur in children under the age of 5 years.
However, the first malaria vaccine recommended by the World Health Organization (WHO) …
However, the first malaria vaccine recommended by the World Health Organization (WHO) …
[HTML][HTML] Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates
As SARS-CoV-2 variants continue evolving, testing updated vaccines in non-human
primates remains important for guiding human clinical practice. To date, such studies have …
primates remains important for guiding human clinical practice. To date, such studies have …
[HTML][HTML] Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection
The generation of high-quality antibody responses to Plasmodium falciparum (Pf)
circumsporozoite protein (PfCSP), the primary surface antigen of Pf sporozoites, is …
circumsporozoite protein (PfCSP), the primary surface antigen of Pf sporozoites, is …
[HTML][HTML] Heterotypic interactions drive antibody synergy against a malaria vaccine candidate
RJ Ragotte, D Pulido, AM Lias, D Quinkert… - Nature …, 2022 - nature.com
Understanding mechanisms of antibody synergy is important for vaccine design and
antibody cocktail development. Examples of synergy between antibodies are well …
antibody cocktail development. Examples of synergy between antibodies are well …
[HTML][HTML] A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum
Potent and durable vaccine responses will be required for control of malaria caused by
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
Plasmodium falciparum (Pf). RTS, S/AS01 is the first, and to date, the only vaccine that has …
[HTML][HTML] Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein
LT Wang, LS Pereira, PK Kiyuka, A Schön… - PLoS …, 2021 - journals.plos.org
Combinations of monoclonal antibodies (mAbs) against different epitopes on the same
antigen synergistically neutralize many viruses. However, there are limited studies …
antigen synergistically neutralize many viruses. However, there are limited studies …
[HTML][HTML] Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection
MC Aguirre-Botero, LT Wang, P Formaglio… - Cell reports, 2023 - cell.com
Human monoclonal antibodies (hmAbs) targeting the Plasmodium falciparum
circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for …
circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for …