Traumatic brain injury and risk of neurodegenerative disorder

BL Brett, RC Gardner, J Godbout, K Dams-O'Connor… - Biological …, 2022 - Elsevier
Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …

[HTML][HTML] Neural stem cell-derived exosomes and regeneration: cell-free therapeutic strategies for traumatic brain injury

L Zhong, J Wang, P Wang, X Liu, P Liu… - Stem Cell Research & …, 2023 - Springer
Regenerative repair of the brain after traumatic brain injury (TBI) remains an extensive
clinical challenge, inspiring intensified interest in therapeutic approaches to explore superior …

[HTML][HTML] Microglia coordinate cellular interactions during spinal cord repair in mice

FH Brennan, Y Li, C Wang, A Ma, Q Guo, Y Li… - Nature …, 2022 - nature.com
Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated …

[HTML][HTML] Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males

H Abou-El-Hassan, RM Rezende, S Izzy… - Nature …, 2023 - nature.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and
adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta …

[HTML][HTML] Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction

M Kodali, LN Madhu, RL Reger, B Milutinovic… - Brain, behavior, and …, 2023 - Elsevier
Traumatic brain injury (TBI) leads to lasting brain dysfunction with chronic
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …

[HTML][HTML] Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases

N Javanmehr, K Saleki, P Alijanizadeh… - Journal of …, 2022 - Springer
Microglia represent the first line of immune feedback in the brain. Beyond immune
surveillance, they are essential for maintaining brain homeostasis. Recent research has …

[HTML][HTML] Molecular mechanisms underlying neuroinflammation elicited by occupational injuries and toxicants

D Pathak, K Sriram - International Journal of Molecular Sciences, 2023 - mdpi.com
Occupational injuries and toxicant exposures lead to the development of neuroinflammation
by activating distinct mechanistic signaling cascades that ultimately culminate in the …

[HTML][HTML] Neuroinflammation following traumatic brain injury: take it seriously or not

R Zheng, K Lee, Z Qi, Z Wang, Z Xu, X Wu… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …

Amplified gliosis and interferon-associated inflammation in the aging brain following diffuse traumatic brain injury

LM Wangler, CE Bray, JM Packer, ZM Tapp… - Journal of …, 2022 - Soc Neuroscience
Traumatic brain injury (TBI) is associated with chronic psychiatric complications and
increased risk for development of neurodegenerative pathology. Aged individuals account …

The meningeal transcriptional response to traumatic brain injury and aging

AC Bolte, DA Shapiro, AB Dutta, WF Ma, KR Bruch… - Elife, 2023 - elifesciences.org
Emerging evidence suggests that the meningeal compartment plays instrumental roles in
various neurological disorders, however, we still lack fundamental knowledge about …