Schizophrenia risk from complex variation of complement component 4

A Sekar, AR Bialas, H De Rivera, A Davis… - Nature, 2016 - nature.com
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms.
Schizophrenia's strongest genetic association at a population level involves variation in the …

[HTML][HTML] Emerging roles of complement in psychiatric disorders

M Druart, C Le Magueresse - Frontiers in psychiatry, 2019 - frontiersin.org
The complement system consists of more than 30 proteins that have long been known to
participate to the immune defence against pathogens and to the removal of damaged cells …

[HTML][HTML] Inflammation and viral infection as disease modifiers in schizophrenia

HC Klein, PC Guest, H Dobrowolny, J Steiner - Frontiers in Psychiatry, 2023 - frontiersin.org
Numerous studies have now implicated a role for inflammation in schizophrenia. However,
many aspects surrounding this aspect of the disease are still controversial. This controversy …

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

H Moradi Chameh, S Rich, L Wang, FD Chen… - Nature …, 2021 - nature.com
In the human neocortex coherent interlaminar theta oscillations are driven by deep cortical
layers, suggesting neurons in these layers exhibit distinct electrophysiological properties. To …

Blood-Based protein changes in childhood are associated with increased risk for later psychotic disorder: evidence from a nested case–control study of the ALSPAC …

JA English, LM Lopez, A O'Gorman… - Schizophrenia …, 2018 - academic.oup.com
The identification of early biological changes associated with the psychotic disorder (PD) is
important as it may provide clues to the underlying pathophysiological mechanisms. We …

Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress

M Föcking, S Sabherwal, HM Cates, C Scaife… - Molecular …, 2021 - nature.com
The complement cascade is a major component of the immune defence against infection,
and there is increasing evidence for a role of dysregulated complement in major psychiatric …

Autism and psychosis: Clinical implications for depression and suicide

R Upthegrove, A Abu-Akel, K Chisholm, A Lin… - Schizophrenia …, 2018 - Elsevier
There is increasing recognition of the co-occurrence of autism and schizophrenia spectrum
disorders. However, the clinical significance of this on outcomes such as depression and …

Causal pathways, random walks and tortuous paths: Moving from the descriptive to the etiological in psychiatry

K Tabb, KF Schaffner, KS Kendler… - Philosophical issues in …, 2017 - books.google.com
Over the last decades a consensus position has formed among psychiatrists and
philosophers that progress in psychiatric nosology consists in the validation of descriptive …

Psychoses by attacks from subverted mast cells: a role for arterial intramural flow badly steered by the nasal ganglia?

GRS Treviranus - Psychiatria Danubina, 2020 - hrcak.srce.hr
PSYCHOSES BY ATTACKS FROM SUBVERTED MAST CELLS: A ROLE FOR ARTERIAL
INTRAMURAL FLOW BADLY STEERED BY THE NASAL GANGLIA? Page 1 S93 …

Blood assessment of the expression levels of matrix metalloproteinase 9 (MMP9) and its natural inhibitor, TIMP1 genes in Iranian schizophrenic patients

S Rahimi, A Sayad, E Moslemi, S Ghafouri-Fard… - Metabolic Brain …, 2017 - Springer
Schizophrenia (SCZ) is the most severe chronic mental disorder characterized by abnormal
social behavior and disrupted emotions and thought. Like other complex …