Therapy resistance is a characteristic of cancer cells that significantly reduces the
effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent …

Gout is the most common form of inflammatory arthritis and is a multifactorial disease
typically characterized by hyperuricemia and monosodium urate crystal deposition …

Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant
metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a …

A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to
the formation of monosodium urate crystals. The clinical features of gout result from an …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some
cases, treatment can increase patient survival and reduce cancer recurrence, in many …

The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …

Hyperuricaemia (increased serum urate concentration) occurs mainly in higher primates,
including in humans, because of inactivation of the gene encoding uricase during primate …

The pathophysiological nature of the common ABCG2 gout and hyperuricemia associated
variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort …

Disorders of uric acid metabolism may be associated with pathological processes in many
diseases, including diabetes mellitus, cardiovascular disease, and kidney disease. These …