Genetic architecture of schizophrenia: a review of major advancements
SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …
technological advancements have led to a substantial increase in knowledge of the genetic …
Toward recovery in schizophrenia: Current concepts, findings, and future research directions
T Onitsuka, Y Hirano, T Nakazawa… - Psychiatry and …, 2022 - Wiley Online Library
Schizophrenia was initially defined as “dementia praecox” by E. Kraepelin, which implies
progressive deterioration. However, recent studies have revealed that early effective …
progressive deterioration. However, recent studies have revealed that early effective …
Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …
[PDF][PDF] Changes in genome architecture and transcriptional dynamics progress independently of sensory experience during post-natal brain development
Both transcription and three-dimensional (3D) architecture of the mammalian genome play
critical roles in neurodevelopment and its disorders. However, 3D genome structures of …
critical roles in neurodevelopment and its disorders. However, 3D genome structures of …
Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia
By meta-analyzing the whole-exomes of 24,248 cases and 97,322 controls, we implicate
ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for …
ultra-rare coding variants (URVs) in ten genes as conferring substantial risk for …
Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders
K Obi-Nagata, N Suzuki, R Miyake, ML MacDonald… - Science …, 2023 - science.org
Human genetics strongly support the involvement of synaptopathy in psychiatric disorders.
However, trans-scale causality linking synapse pathology to behavioral changes is lacking …
However, trans-scale causality linking synapse pathology to behavioral changes is lacking …
Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility
Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …
Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability
We analyzed 131 human brains (44 neurotypical, 19 with Tourette syndrome, 9 with
schizophrenia, and 59 with autism) for somatic mutations after whole genome sequencing to …
schizophrenia, and 59 with autism) for somatic mutations after whole genome sequencing to …
Exome sequencing in obsessive–compulsive disorder reveals a burden of rare damaging coding variants
M Halvorsen, J Samuels, Y Wang, BD Greenberg… - Nature …, 2021 - nature.com
Obsessive–compulsive disorder (OCD) affects 1–2% of the population, and, as with other
complex neuropsychiatric disorders, it is thought that rare variation contributes to its genetic …
complex neuropsychiatric disorders, it is thought that rare variation contributes to its genetic …