[PDF][PDF] The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

KE de Visser, JA Joyce - Cancer Cell, 2023 - cell.com
Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Tertiary lymphoid structures and B cells: An intratumoral immunity cycle

WH Fridman, M Meylan, G Pupier, A Calvez… - Immunity, 2023 - cell.com
The generation of anti-tumor immunity in the draining lymph nodes is known as the cancer
immunity cycle. Accumulating evidence supports the occurrence of such a cycle at tumor …

[HTML][HTML] Antibodies against endogenous retroviruses promote lung cancer immunotherapy

KW Ng, J Boumelha, KSS Enfield, J Almagro, H Cha… - Nature, 2023 - nature.com
B cells are frequently found in the margins of solid tumours as organized follicles in ectopic
lymphoid organs called tertiary lymphoid structures (TLS),. Although TLS have been found to …

T follicular helper cells in cancer

N Gutiérrez-Melo, D Baumjohann - Trends in cancer, 2023 - cell.com
T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated
immune responses. Although the crucial function of these CD4+ T cells in infection and …

Defining and using immune archetypes to classify and treat cancer

AJ Combes, B Samad, MF Krummel - Nature Reviews Cancer, 2023 - nature.com
Tumours are surrounded by a host immune system that can suppress or promote tumour
growth. The tumour microenvironment (TME) has often been framed as a singular entity …

CT radiomics to predict macrotrabecular-massive subtype and immune status in hepatocellular carcinoma

Z Feng, H Li, Q Liu, J Duan, W Zhou, X Yu, Q Chen… - Radiology, 2022 - pubs.rsna.org
Background Macrotrabecular-massive (MTM) subtype of hepatocellular carcinoma (HCC) is
an aggressive variant associated with angiogenesis and immunosuppressive tumor …

[HTML][HTML] Predictive biomarkers of colon cancer immunotherapy: Present and future

W Hou, C Yi, H Zhu - Frontiers in immunology, 2022 - frontiersin.org
Immunotherapy has revolutionized colon cancer treatment. Immune checkpoint inhibitors
(ICIs) have shown clinical benefits for colon cancer patients, especially those with high …

[PDF][PDF] B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity

CM Laumont, BH Nelson - Cancer Cell, 2023 - cell.com
Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions

G Lei, L Zhuang, B Gan - Cancer cell, 2024 - cell.com
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

The cancer epitope database and analysis resource (CEDAR)

Z Koşaloğlu-Yalçın, N Blazeska, R Vita… - Nucleic acids …, 2023 - academic.oup.com
Abstract We established The Cancer Epitope Database and Analysis Resource (CEDAR) to
catalog all epitope data in the context of cancer. The specific molecular targets of adaptive T …