cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment

H Zhang, Y Liu, J Liu, J Chen, J Wang, H Hua… - Journal of Hematology & …, 2024 - Springer
Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

Emerging roles of MITF as a crucial regulator of immunity

A Lee, J Lim, JS Lim - Experimental & Molecular Medicine, 2024 - nature.com
Microphthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper
transcription factor (bHLH-Zip), has been identified as a melanocyte-specific transcription …

cAMP/PKA signaling regulates TDP-43 aggregation and mislocalization

DM Ho, M Shaban, F Mahmood… - Proceedings of the …, 2024 - National Acad Sciences
Cytoplasmic mislocalization and aggregation of TDP-43 protein are hallmarks of
amyotrophic lateral sclerosis (ALS) and are observed in the vast majority of both familial and …

CREB Is Indispensable to KIT Function in Human Skin Mast Cells—A Positive Feedback Loop between CREB and KIT Orchestrates Skin Mast Cell Fate

G Bal, J Schneikert, Z Li, K Franke, SR Tripathi… - Cells, 2023 - mdpi.com
Skin mast cells (MCs) are critical effector cells in acute allergic reactions, and they contribute
to chronic dermatoses like urticaria and atopic and contact dermatitis. KIT represents the …

[HTML][HTML] Function and regulation of nitric oxide signaling in Drosophila

S Jeong - Molecules and Cells, 2023 - Elsevier
Nitric oxide (NO) serves as an evolutionarily conserved signaling molecule that plays an
important role in a wide variety of cellular processes. Extensive studies in Drosophila …

Neuroprotective effects of polyphyllin VI against rotenone-induced toxicity in SH-SY5Y cells

L Li, Z Chen, C Hao - Brain Research, 2024 - Elsevier
Background A substantial body of evidence is drawing connections between Parkinson's
disease (PD) and the phenomena of oxidative stress and mitochondrial dysfunction …

Transcriptomic Profiling after In Vitro Δ8-THC Exposure Shows Cytoskeletal Remodeling in Trauma-Injured NSC-34 Cell Line

L Chiricosta, S D'Angiolini, A Gugliandolo… - Pharmaceuticals, 2023 - mdpi.com
Neuronal cell death is a physiological process that, when uncontrollable, leads to
neurodegenerative disorders like spinal cord injury (SCI). SCI represents one of the major …

Effects of Artificial Sugar Supplementation on the Composition and Nutritional Potency of Honey from Apis cerana

Y Hu, J Liu, Q Pan, X Shi, X Wu - Insects, 2024 - mdpi.com
Simple Summary In the global beekeeping industry, supplementary feeding is crucial for bee
colony maintenance. Beekeepers commonly use sugar syrup as an artificial supplement, yet …

Integrated analyses of transcriptomics and network pharmacology reveal leukocyte characteristics and functional changes in subthreshold depression, elucidating the …

K Li, L You, J Zhen, G Huang, T Wang, Y Cai… - Journal of Traditional …, 2024 - Elsevier
Objective To investigate the molecular mechanism and identify potential drugs for
subthreshold depression (SD), and elucidate the detalied mechanism of Danzhi Xiaoyao …

[PDF][PDF] 江泉黑猪PLAG1基因多态性及其与生长性能的关联分析

马小燕, 王文文, 郑凤玲, 刘汇鑫, 许飞… - 农业生物技术 …, 2024 - journal05.magtech.org.cn
摘要多形性腺瘤基因1 (plemorphic adenoma gene 1, PLAG1) 在调控畜, 禽生长发育方面具有
重要影响. 为探究江泉黑猪PLAG1 的单核苷酸多态性及其与生长性能的关系, 本研究以277 …