Recurrence of advanced melanoma after therapy is a major risk factor for reduced survival,
and treatment options are limited. Antitumor immune memory plays a critical role in …

ATRX is a tumor suppressor that has been associated with protection from DNA replication
stress, purportedly through resolution of difficult-to-replicate G-quadruplex (G4) DNA …

Mammalian hair cells do not functionally regenerate in adulthood but can regenerate at
embryonic and neonatal stages in mice by direct transdifferentiation of neighboring …

Histone marks, carriers of epigenetic information, regulate gene expression. In mammalian
cells, H3K36me3 is mainly catalyzed by SETD2 at gene body regions. Here, we find that in …

The Anopheles mosquito is one of thousands of species in which sex differences play a
central part in their biology, as only females need a blood meal to produce eggs. Sex …

DNA–protein interactions are central to fundamental cellular processes, yet widely
implemented technologies for measuring these interactions on a genome scale in bacteria …

Long known as the site of ribosome biogenesis, the nucleolus is increasingly recognized for
its role in shaping three-dimensional (3D) genome organization. Still, the mechanisms …

Acute myeloid and lymphoid leukemias often harbor chromosomal translocations involving
the KMT2A gene, encoding the KMT2A lysine methyltransferase (also known as mixed …

For more than a century, formalin-fixed paraffin-embedded (FFPE) sample preparation has
been the preferred method for long-term preservation of biological material. However, the …

Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors driven by populations
of cancer stem cells (CSCs). However, few molecular mechanisms critical for CSC …