Measuring biological age using omics data
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
Epigenetic regulation of aging: implications for interventions of aging and diseases
K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
Organ aging signatures in the plasma proteome track health and disease
Animal studies show aging varies between individuals as well as between organs within an
individual,,–, but whether this is true in humans and its effect on age-related diseases is …
individual,,–, but whether this is true in humans and its effect on age-related diseases is …
Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality
Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …
predictors of health outcomes and mortality in older populations. However, it is unknown …
Risk factors of severe COVID-19: a review of host, viral and environmental factors
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …
asymptomatic infections to severe disease and death. Understanding the risk factors of …
Epigenetic age prediction
DJ Simpson, T Chandra - Aging cell, 2021 - Wiley Online Library
Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …
Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status
Slower epigenetic aging is associated with exposure to green space (greenness); however,
the longitudinal relationship has not been well studied, particularly in minority groups. We …
the longitudinal relationship has not been well studied, particularly in minority groups. We …
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: The DAMA study
Several biomarkers of healthy aging have been proposed in recent years, including the
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …
Biomarkers of aging for the identification and evaluation of longevity interventions
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
longevity interventions in humans have become key goals of this field. Biomarkers of aging …