Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model

YH Hung, M Capeling, JW Villanueva, M Kanke… - BMC genomics, 2023 - Springer
Background MicroRNAs (miRNAs) are important post-transcriptional gene regulators
controlling cellular lineage specification and differentiation during embryonic development …

AQP1 Deficiency Drives Phthalate-Induced Epithelial Barrier Disruption through Intestinal Inflammation

Y Zhao, ZY Hu, M Lou, FW Jiang… - Journal of Agricultural …, 2024 - ACS Publications
Di-2-ethylhexyl phthalate (DEHP) is frequently used as a plasticizer to enhance the plasticity
and durability of agricultural products, which pose adverse effects to human health and the …

Gut Bacterial Community Determines the Therapeutic Effect of Ginsenoside on Canine Inflammatory Bowel Disease by Modulating the Colonic Mucosal Barrier

A Mao, W Zhao, Y Zhu, F Kong, D Chen, H Si, C Xu - Microorganisms, 2023 - mdpi.com
Inflammatory bowel disease (IBD) comprises systemic inflammatory conditions primarily
affecting the gastrointestinal tract, including Crohn's disease and ulcerative colitis. This …

Interleukin‐1 family cytokines at the crossroads of microbiome regulation in barrier health and disease

P Narros‐Fernández… - The FEBS …, 2024 - Wiley Online Library
Recent advances in understanding how the microbiome can influence both the physiology
and the pathogenesis of disease in humans have highlighted the importance of gaining a …

Cholecystokinin receptor antagonist improves efficacy of chemotherapy in murine models of pancreatic cancer by altering the tumor microenvironment

ZX Malchiodi, H Cao, MD Gay, A Safronenka, S Bansal… - Cancers, 2021 - mdpi.com
Simple Summary Our research team has identified the cholecystokinin-B receptor (or CCK-
BR) as a novel target for treatment of pancreatic cancer. CCK-BRs are over-expressed in …

Posttranscriptional Regulation of Intestinal Mucosal Growth and Adaptation by Noncoding RNAs in Critical Surgical Disorders

CA Cairns, L Xiao, JY Wang - Journal of Investigative Surgery, 2024 - Taylor & Francis
The human intestinal epithelium has an impressive ability to respond to insults and its
homeostasis is maintained by well-regulated mechanisms under various pathophysiological …

Effects of resveratrol on tight junction proteins and the Notch1 pathway in an HT-29 cell model of inflammation induced by lipopolysaccharide

Y Luo, X Yu, P Zhao, J Huang, X Huang - Inflammation, 2022 - Springer
Ulcerative colitis (UC) is closely associated with disruption of intestinal epithelial tight
junction proteins. A variety of studies have confirmed that resveratrol (RSV), a natural …

[HTML][HTML] 1, 8-cineole ameliorates colon injury by downregulating macrophage M1 polarization via inhibiting the HSP90-NLRP3-SGT1 complex

S Ma, B Yang, Y Du, Y Lv, J Liu, Y Shi, T Huang… - Journal of …, 2023 - Elsevier
Ulcerative colitis (UC) is characterized by chronic relapsing intestinal inflammation.
Currently, there is no effective treatment for the disease. According to our preliminary data, 1 …

Sijunzi decoction targets IL1B and TNF to reduce Neutrophil Extracellular Traps (NETs) in ulcerative colitis: evidence from silicon prediction and experiment validation

D Zhang, S Duan, Z He, Z Zhu, Z Li, Q Yi… - Drug Design …, 2023 - Taylor & Francis
Purpose This study was conducted to explore the mechanism of Sijunzi Decoction (SJZ) in
the treatment of ulcerative colitis (UC). Methods The study aimed to investigate the active …

Stevioside Ameliorates Prenatal Obesity Induced Postpartum Depression: The Potential Role of Gut Barrier Homeostasis

J Ye, R Shi, H Fan, D Wang, C Xiao… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Postpartum depression and cognitive impairment are the common complications of
prenatal obesity. Stevioside is a non‐nutritive natural sweetener with antioxidant and anti …