Inflammatory cytokines including TNF-α and IL-1β impair intestinal barrier function in aging
by disrupting intestinal tight junction integrity. Icariin (ICA) has a variety of pharmacological …

Elderly-onset inflammatory bowel disease [IBD] patients exhibit a distinct natural history
compared to younger IBD patients, with unique disease phenotypes, differential responses …

Imidacloprid is the most widely used pesticide of the neonicotinoid class. Neonicotinoid
toxicities against various insects are well known. Nevertheless, there are rising evidences …

Excessive release of inflammatory cytokines has been considered as a major cause of
chronic inflammation, resulting in intestinal barrier disruption that leads to inflammatory …

Intestinal epithelial cells are an essential barrier in human gastrointestinal tract, and healing
of epithelial wound is a key process in many intestinal diseases. α‐Lipoic acid (ALA) was …

The latest guideline about ulcerative colitis (UC) clinical practice stresses that mucosal
healing, rather than anti-inflammation, is the main target in UC clinical management. Current …

Accumulating evidence has demonstrated that diet-derived gut microbiota participates in the
regulation of host metabolism and becomes the foundation for precision-based nutritional …

IL-1β is an important cytokine implicated in the progression of inflammatory bowel disease
(IBD) and intestinal barrier dysfunction. The polyphenolic compound, geraniin, possesses …

Background Inflammatory bowel disease (IBD) was a chronic intestinal disease related to
autoimmunity, and its pathogenesis was complex. Forsythia suspensa (F. suspensa) had …

BACKGROUND: Tissue harvesting at the time of surgery offers surgeons and scientists a
unique opportunity to discover and better understand disease pathophysiology. Tissue …