[HTML][HTML] Genetic and epigenetic regulation of human aging and longevity

BJ Morris, BJ Willcox, TA Donlon - … Acta (BBA)-Molecular Basis of Disease, 2019 - Elsevier
Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

Role of the mitochondrial protein import machinery and protein processing in heart disease

F Zhao, MH Zou - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
Mitochondria are essential organelles for cellular energy production, metabolic
homeostasis, calcium homeostasis, cell proliferation, and apoptosis. About 99% of …

Genetic risk factors related to coronary artery disease and role of transforming growth factor Beta 1 polymorphisms

D Malinowski, O Bochniak, K Luterek-Puszyńska… - Genes, 2023 - mdpi.com
Coronary artery disease (CAD) is one of the leading causes of mortality globally and has
long been known to be heritable; however, the specific genetic factors involved have yet to …

The impact of pharmacogenomics in personalized medicine

DB Singh - Current Applications of Pharmaceutical Biotechnology, 2020 - Springer
Recent advances in Pharmacogenomics have made it possible to understand the reasons
behind the different response of a drug. Discovery of genetic variants and its association …

Association between APOE polymorphisms and lipid profile in Mexican Amerindian population

JJ Martínez‐Magaña… - Molecular genetics & …, 2019 - Wiley Online Library
Abstract Background Apolipoprotein E (ApoE) is a glycoprotein that plays an important role
in lipid homeostasis at both cerebral and systemic levels. Moreover, the differential …

Immune-related potential biomarkers and therapeutic targets in coronary artery disease

C Liu, J Liu, Y Zhang, X Wang, Y Guan - Frontiers in Cardiovascular …, 2023 - frontiersin.org
Background Coronary artery disease (CAD) is a complex illness with unknown
pathophysiology. Peripheral biomarkers are a non-invasive method required to track the …

A new preoperative prognostic system combining CRP and CA199 for patients with intrahepatic cholangiocarcinoma

BH Zheng, LX Yang, QM Sun, HK Fan… - Clinical and …, 2017 - journals.lww.com
OBJECTIVES: In this study, we aimed at investigating the preoperatively available
prognostic factors for intrahepatic cholangiocarcinoma (ICC) patients and proposing a new …

MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response

D Lin, J Yu, L Lin, Q Ou, H Quan - Scientific Reports, 2023 - nature.com
Lack of efficient insulin secretion from the pancreas can lead to impaired glucose tolerance
(IGT), prediabetes, and diabetes. We have previously identified two IGT-associated single …

[图书][B] Buku Ajar Nutrigenomik dan Nutrigenetik Bagi Mahasiswa Gizi

HFL Muhammad, DC Sulistyoningrum, RJ Kusuma… - 2021 - books.google.com
Peran bidang ilmu nutrigenetik dan nutrigenomik memperoleh perhatian selama dua
dekade ini berkaitan dengan penyakit degeneratif. Nutrigenetik dan nutrigenomik …

A TOMM40/APOE allele encoding APOE‐E3 predicts high likelihood of late‐onset Alzheimer's disease in autopsy cases

SM Soyal, M Kwik, O Kalev, S Lenz… - Molecular genetics & …, 2020 - Wiley Online Library
Background The APOE‐ε4 allele is an established risk factor for Alzheimer's disease (AD).
TOMM40 located adjacent to APOE has also been implicated in AD but reports of TOMM40 …