Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …

Interleukin‐6 blocking agents for treating COVID‐19: a living systematic review

L Ghosn, R Assi, T Evrenoglou… - Cochrane database …, 2023 - cochranelibrary.com
Background It has been reported that people with COVID‐19 and pre‐existing
autoantibodies against type I interferons are likely to develop an inflammatory cytokine storm …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis

IM Tleyjeh, Z Kashour, M Damlaj, M Riaz… - Clinical Microbiology …, 2021 - Elsevier
Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses

M Koutsakos, LC Rowntree, L Hensen, BY Chua… - Cell Reports …, 2021 - cell.com
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …

Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into context

F Angriman, BL Ferreyro, L Burry, E Fan… - The lancet respiratory …, 2021 - thelancet.com
The pleiotropic cytokine interleukin-6 (IL-6) has been implicated in the pathogenesis of
COVID-19, but uncertainty remains about the potential benefits and harms of targeting IL-6 …

COVID-19 and risk for mental disorders among adults in Denmark

V Nersesjan, RHB Christensen, D Kondziella… - JAMA …, 2023 - jamanetwork.com
Importance Psychiatric outcomes after COVID-19 have been of high concern during the
pandemic; however, studies on a nationwide level are lacking. Objective To estimate the risk …

Repurposing of biologic and targeted synthetic anti-rheumatic drugs in COVID-19 and hyper-inflammation: a comprehensive review of available and emerging …

G Cavalli, N Farina, C Campochiaro… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is a condition caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). Severe cases of COVID-19 result in acute …

Non-coding RNAs in COVID-19: emerging insights and current questions

T Plowman, D Lagos - Non-coding RNA, 2021 - mdpi.com
The highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged as the causative agent of coronavirus disease 2019 (COVID-19) in late 2019 …

Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway

A Dritsoula, L Dowsett, C Pilotti, MN O'Connor… - Scientific reports, 2022 - nature.com
Abstract Leucine-rich α-2-glycoprotein 1 (LRG1) is a secreted glycoprotein that under
physiological conditions is produced predominantly by the liver. In disease, its local …

NOTCH signaling in COVID-19: A central hub controlling genes, proteins, and cells that mediate SARS-CoV-2 entry, the inflammatory response, and lung regeneration

P Baindara, MB Sarker, AP Earhart… - Frontiers in Cellular …, 2022 - frontiersin.org
In the lungs of infected individuals, the downstream molecular signaling pathways induced
by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) are incompletely …