Plant-derived polysaccharides activate dendritic cell-based anti-cancer immunity

S Kikete, L Luo, B Jia, L Wang, G Ondieki, Y Bian - Cytotechnology, 2018 - Springer
Today, cancers pose a major public health burden. Although a myriad of cancer treatments
are available, only a few have achieved clinical efficacy. This is partly attributed to cancers …

Adjuvant-active aqueous extracts from Artemisia rupestris L. improve immune responses through TLR4 signaling pathway

A Zhang, Y Yang, Y Wang, G Zhao, X Yang, D Wang… - Vaccine, 2017 - Elsevier
Activating innate immunity by an adjuvant is required in vaccine development. The study
aims to investigate adjuvant effects of aqueous extracts of Artemisia rupestris L.(AEAR) in …

Effect of Human Mesenchymal Stem Cells on Xenogeneic T and B Cells Isolated from Lupus‐Prone MRL.Faslpr Mice

HK Lee, EY Kim, HS Kim, EJ Park, HJ Lee… - Stem Cells …, 2020 - Wiley Online Library
Systemic lupus erythematosus (SLE) is an autoimmune disease, which is characterized by
hyperactivation of T and B cells. Human mesenchymal stem cells (hMSCs) ameliorate the …

Menthol nanoliposomes enhanced anti-tumor immunotherapy by increasing lymph node homing of dendritic cell vaccines

X Li, Y Wu, S Wang, J Liu, T Zhang, Y Wei, L Zhu… - Clinical …, 2022 - Elsevier
Menthol, a cyclic terpene alcohol, plays a critical role in overcoming the blood-brain barrier
and stratum corneum barrier. Herein, we innovatively propose a menthol nanoliposome …

A polysaccharide isolated from Pueraria lobata enhances maturation of murine dendritic cells

HS Kim, BR Shin, HK Lee, YJ Kim, MJ Park… - International journal of …, 2013 - Elsevier
Maturation of dendritic cells (DCs) is a critical factor for initiating the immune response.
However, DC maturation is usually attenuated in the tumor microenvironment, which is an …

Cytokine-induced killer cells interact with tumor lysate–pulsed dendritic cells via CCR5 signaling

HK Lee, YG Kim, JS Kim, EJ Park, B Kim, KH Park… - Cancer letters, 2016 - Elsevier
The antitumor activity of cytokine-induced killer (CIK) cells can be increased by co-culturing
them with tumor lysate–pulsed dendritic cells (tDCs); this phenomenon has been studied …

Low-dose radiation promotes dendritic cell migration and IL-12 production via the ATM/NF-KappaB pathway

N Yu, S Wang, X Song, L Gao, W Li, H Yu… - Radiation …, 2018 - meridian.allenpress.com
For dendritic cells (DCs) to initiate an immune response, their ability to migrate and to
produce interleukin-12 (IL-12) is crucial. It has been previously shown that low-dose …

Promoting effect of polysaccharide isolated from Mori fructus on dendritic cell maturation

BR Shin, HS Kim, MJ Yun, HK Lee, YJ Kim… - Food and chemical …, 2013 - Elsevier
Maturation of dendritic cells (DCs) is usually attenuated in the tumor microenvironment,
which is an important immunological problem in DC-based immunotherapy of cancer. In this …

A TLR5 agonist enhances CD8+ T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease

X Ding, G Bian, ND Leigh, J Qiu… - The Journal of …, 2012 - journals.aai.org
Allogeneic hematopoietic cell transplantation is an established treatment for hematologic
and nonhematologic malignancies. Donor-derived immune cells can identify and attack host …

[HTML][HTML] Natural polysaccharides exert anti-tumor effects as dendritic cell immune enhancers

H Xiong, X Han, L Cai, H Zheng - Frontiers in Oncology, 2023 - frontiersin.org
With the development of immunotherapy, the process of tumor treatment is also moving
forward. Polysaccharides are biological response modifiers widely found in plants, animals …