Sex and gender dimorphisms are found in a large variety of diseases, including sepsis and
septic shock which are more prevalent in men than in women. Animal models show that the …

Type 2 diabetes is a chronic disease associated with micro-and macro-vascular
complications, including myocardial ischemia, and also with a specific and intrinsic cardiac …

OBJECTIVES: Preclinical studies provide an opportunity to evaluate the relationship
between sex and sepsis, and investigate underlying mechanisms in a controlled …

The administration of β-blockers in patients with sepsis is a trending topic in intensive care
medicine since the landmark study by Morelli and colleagues, showing a striking decrease …

Although epidemiologic research has demonstrated significant differences in incidence and
outcomes of sepsis according to sex, their underlying biological mechanisms are poorly …

Most infectious diseases are unequally distributed between male and female subjects. This
sex dimorphism is confirmed by epidemiologic studies which suggest an increased number …

Purpose This meta-analysis aims to identify whether patients with sepsis who have
persistent tachycardia despite initial resuscitation can benefit from ultrashort-acting β …

Increased sympathetic nervous system (SNS) activity leads to increased risk of
cardiovascular morbidity and mortality. This study investigated whether there were sex …

Background Landiolol hydrochloride, a highly cardio-selective beta-1 blocker with an ultra-
short-acting half-life of 4 minutes, was originally approved by Japan for treatment of …

Background Sex differences in sepsis are underexplored and incompletely understood.
Cardiac function in early sepsis is pivotal in determining survival; hyperdynamic left …