Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects
In the last decade, the development of messenger RNA (mRNA) therapeutics by lipid
nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of …
nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of …
[HTML][HTML] Omicron variant: Current insights and future directions
R Rana, R Kant, RS Huirem, D Bohra… - Microbiological …, 2022 - Elsevier
The global COVID-19 outbreak has returned with the identification of the SARS-CoV-2
Omicron variant (B. 1.1. 529) after appearing to be persistently spreading for the more than …
Omicron variant (B. 1.1. 529) after appearing to be persistently spreading for the more than …
Omicron variant (B. 1.1. 529): infectivity, vaccine breakthrough, and antibody resistance
The latest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron
(B. 1.1. 529) has ushered panic responses around the world due to its contagious and …
(B. 1.1. 529) has ushered panic responses around the world due to its contagious and …
Omicron BA. 2 (B. 1.1. 529.2): high potential for becoming the next dominant variant
The Omicron variant has three subvariants: BA. 1 (B. 1.1. 529.1), BA. 2 (B. 1.1. 529.2), and
BA. 3 (B. 1.1. 529.3). BA. 2 is found to be able to alarmingly reinfect patients originally …
BA. 3 (B. 1.1. 529.3). BA. 2 is found to be able to alarmingly reinfect patients originally …
Emerging vaccine-breakthrough SARS-CoV-2 variants
The surge of COVID-19 infections has been fueled by new SARS-CoV-2 variants, namely
Alpha, Beta, Gamma, Delta, and so forth. The molecular mechanism underlying such surge …
Alpha, Beta, Gamma, Delta, and so forth. The molecular mechanism underlying such surge …
Persistent Laplacian projected Omicron BA. 4 and BA. 5 to become new dominating variants
Due to its high transmissibility, Omicron BA. 1 ousted the Delta variant to become a
dominating variant in late 2021 and was replaced by more transmissible Omicron BA. 2 in …
dominating variant in late 2021 and was replaced by more transmissible Omicron BA. 2 in …
Regional and temporal coordinated mutation patterns in SARS-CoV-2 spike protein revealed by a clustering and network analysis
SARS-CoV-2 has steadily mutated during its spread to> 300 million people throughout the
world. The WHO has designated strains with certain mutations,“variants of concern”(VOC) …
world. The WHO has designated strains with certain mutations,“variants of concern”(VOC) …
A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants
Z Yang, Y Wang, Y Jin, Y Zhu, Y Wu, C Li… - Signal transduction and …, 2021 - nature.com
The current COVID-19 pandemic has heavily burdened the global public health system and
may keep simmering for years. The frequent emergence of immune escape variants have …
may keep simmering for years. The frequent emergence of immune escape variants have …
Optimization and clinical validation of colorimetric reverse transcription loop-mediated isothermal amplification, a fast, highly sensitive and specific COVID-19 …
PA Alves, EG de Oliveira, APM Franco-Luiz… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic unfolded due to the widespread
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission reinforced the …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission reinforced the …
Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody
C Li, W Zhan, Z Yang, C Tu, G Hu, X Zhang, W Song… - Cell, 2022 - cell.com
The effectiveness of SARS-CoV-2 vaccines and therapeutic antibodies have been limited by
the continuous emergence of viral variants and by the restricted diffusion of antibodies from …
the continuous emergence of viral variants and by the restricted diffusion of antibodies from …