[PDF][PDF] Calcium channels, synaptic plasticity, and neuropsychiatric disease

E Nanou, WA Catterall - Neuron, 2018 - cell.com
Voltage-gated calcium channels couple depolarization of the cell-surface membrane to entry
of calcium, which triggers secretion, contraction, neurotransmission, gene expression, and …

An update on the comorbidity of ADHD and ASD: A focus on clinical management

KM Antshel, Y Zhang-James, KE Wagner… - Expert review of …, 2016 - Taylor & Francis
Attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD)
commonly co-occur. With the DSM-5, clinicians are permitted to make an ASD diagnosis in …

Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood

N Dedic, ML Pöhlmann, JS Richter, D Mehta… - Molecular …, 2018 - nature.com
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-
gated L-type calcium channel Ca v 1.2, rank among the most consistent and replicable …

[HTML][HTML] Gene–environment interaction in major depression: focus on experience-dependent biological systems

N Lopizzo, L Bocchio Chiavetto, N Cattane… - Frontiers in …, 2015 - frontiersin.org
Major depressive disorder (MDD) is a multifactorial and polygenic disorder, where multiple
and partially overlapping sets of susceptibility genes interact each other and with the …

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

BPF Rutten, E Vermetten, CH Vinkers, G Ursini… - Molecular …, 2018 - nature.com
In order to determine the impact of the epigenetic response to traumatic stress on post-
traumatic stress disorder (PTSD), this study examined longitudinal changes of genome-wide …

Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stress

M Tang, H Huang, S Li, M Zhou, Z Liu, R Huang… - Translational …, 2019 - nature.com
Chronic stressful occurrences are documented as a vital cause of both depression and
anxiety disorders. However, the stress-induced molecular mechanisms underlying the …

Methylation of serotonin receptor 3A in ADHD, borderline personality, and bipolar disorders: link with severity of the disorders and childhood maltreatment

N Perroud, S Zewdie, L Stenz, W Adouan… - Depression and …, 2016 - Wiley Online Library
Background Serotonin 3A receptor (5‐HT3AR) is associated at the genetic and epigenetic
levels with a variety of psychiatric disorders and interacts with early‐life stress such as …

Decreased brain pH as a shared endophenotype of psychiatric disorders

H Hagihara, VS Catts, Y Katayama, H Shoji… - …, 2018 - nature.com
Although the brains of patients with schizophrenia and bipolar disorder exhibit decreased
brain pH relative to those of healthy controls upon postmortem examination, it remains …

Genetics of attention-deficit/hyperactivity disorder: an update

GC Akutagava-Martins, LA Rohde… - Expert review of …, 2016 - Taylor & Francis
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder
affecting children, adolescents, and adults. The prevalence is estimated at 5 to 7% of school …

Neurodevelopmental perspectives on Wnt signaling in psychiatry

KA Mulligan, BNR Cheyette - Complex Psychiatry, 2017 - karger.com
Mounting evidence indicates that Wnt signaling is relevant to pathophysiology of diverse
mental illnesses including schizophrenia, bipolar disorder, and autism spectrum disorder. In …