Cellular senescence is a kind of cellular state triggered by endogenous or exogenous
stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence …

Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders.
Controlled removal of damaged mitochondria by the autophagic machinery, a process …

Cellular senescence and the senescence‐associated secretory phenotype (SASP)
contribute to age‐related arterial dysfunction, in part, by promoting oxidative stress and …

The theory that oxidative damage caused by mitochondrial free radicals leads to aging has
brought mitochondria into the forefront of aging research. Psychological stress that …

Cardiovascular disease (CVD) has increasing challenges for human health with an
increasingly aging population worldwide, imposing a significant obstacle to the goal of …

Dyslipidaemia plays a prominent role in the genesis of atherosclerotic plaque and the
increased cardiovascular risk in diabetes. Macrophages readily take up atherogenic …

Heart aging is a prevalent cause of cardiovascular diseases among the elderly. NAD+
depletion is a hallmark feature of aging heart, however, the molecular mechanisms that …

Epidemiological data and interventional studies with hormone replacement therapy suggest
that women, at least until menopause, are at decreased cardiovascular risk compared to …

The prevalence of age-related diseases has been progressively increasing worldwide. The
pathogenesis of these disorders, including cancer, is closely associated with an age …

Population aging is one of the most important demographic transformations of our time.
Increasing the “health span”—the proportion of life spent in good health—is a global priority …