Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Cancer biology is profoundly influenced by changes in the epigenome. Because the
dynamic plasticity of the epigenome lends itself well to therapeutic manipulation, the past …

Cellular reprogramming can manipulate the identity of cells to generate the desired cell
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …

Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic
disorders, and autoimmune diseases. Currently, most cell therapy products rely on ex vivo …

Genetic studies in animals and humans indicate that gene mutations that functionally perturb
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …

Much research has been devoted to identify the conditions under which selection favours
flexible individuals or genotypes that are able to modify their growth, development and …

Adult liver progenitor cells are biliary-like epithelial cells that emerge only under injury
conditions in the periportal region of the liver. They exhibit phenotypes of both hepatocytes …

In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of
regulators of gene expression. lncRNAs exhibit several distinctive features that confer …

Recent literature has ascribed that the paracrine action of stem cells is mediated by
exosomes. Exosomes are nano-sized extracellular vesicles (30 to 100 nm) of endocytic …

Since their first discovery, investigations of colorectal cancer stem cells (CSCs) have
revealed some unexpected properties, including a high degree of heterogeneity and …