Development of human respiratory airway models: A review

K Ahookhosh, O Pourmehran, H Aminfar… - European Journal of …, 2020 - Elsevier
Pulmonary drug delivery has gained great interest as an important subject of research over
the past decades given the lung diseases which are affecting millions of people suffer from …

Particle deposition in tracheobronchial airways of an infant, child and adult

Q Deng, C Ou, J Chen, Y Xiang - Science of the Total Environment, 2018 - Elsevier
Background Particle deposition in human airways is important for assessing both health
effects of inhaled particles and therapeutic efficacy of inhaled drug aerosols, but is not well …

Flow structure and particle deposition analyses for optimization of a pressurized metered dose inhaler (pMDI) in a model of tracheobronchial airway

K Ahookhosh, M Saidi, M Mohammadpourfard… - European Journal of …, 2021 - Elsevier
Inhalation therapy plays an important role in management or treatment of respiratory
diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades …

Characterization of dry powder inhaler performance through experimental methods

CA Ruzycki, S Tavernini, AR Martin… - Advanced Drug Delivery …, 2022 - Elsevier
Experimental methods provide means for the quality control of existing DPIs and for
exploring the influence of formulation and device parameters well in advance of clinical trials …

Dry powder inhaler aerosol deposition in a model of tracheobronchial airways: Validating CFD predictions with in vitro data

K Ahookhosh, M Saidi, H Aminfar… - International journal of …, 2020 - Elsevier
Effective drug delivery into the lungs plays an important role in management of pulmonary
diseases that affect millions all around the world. The main objective of this investigation is …

Air pollution is associated with increased incidence-rate of head and neck cancers: A nationally representative ecological study

HO Scussiatto, KM Stenson, S Al-Khudari, MJ Jelinek… - Oral Oncology, 2024 - Elsevier
Introduction Early studies show conflicting findings regarding particulate matter≤ 2.5 μm in
diameter (PM 2.5) exposure and development of head and neck cancers (HNC). We …

Experimental investigation of aerosol deposition through a realistic respiratory airway replica: an evaluation for MDI and DPI performance

K Ahookhosh, S Yaqoubi… - International journal of …, 2019 - Elsevier
Purpose In the present work, a comparison between MDI and DPI for evaluating
performance of the devices were carried out by experimentally investigating the deposition …

A numerical simulation of the airflow and aerosol particle deposition in a realistic airway model of a healthy adult

D Ciloglu, A Karaman - Journal of pharmaceutical sciences, 2022 - Elsevier
Determining the behavior of aerosol drug particles is of vital importance in the treatment of
respiratory tract diseases. Despite the development of imaging techniques in the pulmonary …

A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography

F Lizal, M Belka, J Adam, J Jedelsky… - Proceedings of the …, 2015 - journals.sagepub.com
Researchers have been studying aerosol transport in human lungs for some decades. The
overall lung deposition can be predicted with sufficient precision nowadays. However, the …

Computational evaluation of drug delivery in human respiratory tract under realistic inhalation

A Tiwari, A Jain, AR Paul, SC Saha - Physics of Fluids, 2021 - pubs.aip.org
In recent years, pulmonary diseases have posed severe health problems because of
increasing air pollution. Some of the promising drug delivery devices for administering the …