It is generally thought that many drug molecules are transported across biological
membranes via passive diffusion at a rate related to their lipophilicity. However, the types of …

The ATP-binding cassette (ABC) transporters constitute a large family of membrane proteins,
which transport a variety of compounds through the membrane against a concentration …

Pairs of forward and reverse primers and TaqMan probes speciˆc to each of 46 human ATP-
binding cassette (ABC) transporters and 108 human solute carrier (SLC) transporters were …

A variety of drug transporters expressed in the body control the fate of drugs by affecting
absorption, distribution, and elimination processes. In the small intestine, transporters …

▪ Abstract Recent studies have revealed the import role played by transporters in the renal
and hepatobiliary excretion of many drugs. These transporters exhibit a broad substrate …

There is a growing need for highly accurate in silico and in vitro predictive models to
facilitate drug discovery and development. Results from in vitro permeation studies across …

Pairs of forward and reverse primers and TaqMan probes specific to each of 173 human
solute carrier (SLC) transporters were prepared. The mRNA expression level of each target …

Abstract 17α-Ethinylestradiol (EE) is widely used as the estrogenic component of oral
contraceptives (OC). In vitro and in vivo metabolism studies indicate that EE is extensively …

1. Pharmacokinetic drug interactions can lead to serious adverse events and the evaluation
of a new molecular entity's (NME) drug–drug interaction potential is an integral part of drug …

In this article, aspects of absorption, distribution, metabolism, and excretion have been
described bearing in mind the pathogenesis of allergic diseases and their possible …