The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

Hepatocellular carcinoma (HCC) is a leading cause of death, resulting in over 700 thousand
deaths annually worldwide. Chemotherapy is the primary therapeutic strategy for patients …

Oridonin, as a natural terpenoids found in traditional Chinese herbal medicine Isodon
rubescens (Hemsl.) H. Hara, is widely present in numerous Chinese medicine preparations …

Statistics provided by GLOBOCAN list gastric cancer as the sixth most common, with a
mortality ranking of third highest for the year 2020. In China, a herb called Rabdosia …

Ammonia is one of the major pollutants associated with the main river basins due to
ammonification of uneaten food and animal excretion, which usually brings detrimental …

Cancer is one of the diseases with high morbidity and mortality on a global scale.
Chemotherapy remains the primary treatment option for most cancer patients, including …

The NLRP3 inflammasome is an intracellular sensor and an essential component of the
innate immune system involved in danger recognition. An important hallmark of …

Isodon rubescens is a medicinal and food plant, often eaten as a wild vegetable in ancient
China, and has been widely used for decades to treat sore throats, tonsillitis, colds and …

Pyroptosis is a type of inflammatory cell death that is triggered by the formation of pores on
the cell membrane by gasdermin (GSDM) family proteins. This process activates …