High levels of reactive oxygen species (ROS) are observed in chronic human diseases such
as obesity, type 2 diabetes, atherosclerosis, and cardiovascular diseases. In addition to the …

Cardiovascular disease is a common complication of diabetes and the leading cause of
death among people with diabetes. Because of the huge premature morbidity and mortality …

Amidst several pathophysiological cascades, Advanced Glycation End products (AGEs)
have been identified as a pivotal aetiology behind the pathogenesis and progression of …

Epidemiological studies demonstrate the role of early and intensive glycemic control in the
prevention of micro and macrovascular disease in both type 1 and type 2 diabetes mellitus …

Most diabetes-related complications and causes of death arise from cardiovascular disease
and end-stage renal disease. Amongst the major complications of diabetes mellitus are …

Glucose and fructose metabolism originates the highly reactive byproduct methylglyoxal
(MG), which is a strong precursor of advanced glycation end products (AGE). The MG has …

Damage accumulation in long-living macromolecules (especially extracellular matrix (ECM)
proteins, nuclear pore complex (NPC) proteins, and histones) is a missing hallmark of aging …

The epidermal growth factor receptor (EGFR) belongs to the ErbB-family of receptor tyrosine
kinases that are of importance in oncology. During the last years, substantial evidence …

Reactive oxygen species (ROS) are well known to be involved in oncogene-mediated
cellular transformation. However, the regulatory mechanisms underlying ROS generation in …

Metabolic syndrome (MetS), ie a cluster of physiological and biochemical abnormalities can
lead to diabetic nephropathy (DN). Insulin resistance, impaired fasting glucose are the main …