To better understand transcriptional regulation during human oogenesis and
preimplantation development, we defined stage-specific transcription, which highlighted the …

Single-cell transcriptomics is a versatile tool for exploring heterogeneous cell populations,
but as with all genomics experiments, batch effects can hamper data integration and …

With the rapid development of biotechnology, the number of biological sequences has
grown exponentially. The continuous expansion of biological sequence data promotes the …

Single-cell genomics has now made it possible to create a comprehensive atlas of human
cells. At the same time, it has reopened definitions of a cell's identity and of the ways in …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Understanding the development and function of an organ requires the characterization of all
of its cell types. Traditional methods for visualizing and isolating subpopulations of cells are …

The differences between individual cells can have profound functional consequences, in
both unicellular and multicellular organisms. Recently developed single-cell mRNA …

Of all known cultured stem cell types, pluripotent stem cells (PSCs) sit atop the landscape of
developmental potency and are characterized by their ability to generate all cell types of an …

Single-cell RNA sequencing (scRNA-seq) has broad applications across biomedical
research. One of the key challenges is to ensure that only single, live cells are included in …

Maternal-to-zygotic transition (MZT) is essential for the formation of a new individual, but is
still poorly understood despite recent progress in analysis of gene expression and DNA …