Minority subpopulations within embryonic stem cell cultures display an expanded
developmental potential similar to that of early embryo blastomeres or the early inner cell …

Emerging and seminal studies have shown that cell metabolism influences gene expression
by modifying the epigenome, which can regulate stem cell pluripotency, differentiation, and …

Background During mammalian pre-implantation embryonic development dramatic and
orchestrated changes occur in gene transcription. The identification of the complete changes …

Maternal-to-embryonic transition (MET) is the period in early embryonic development when
maternal RNAs and proteins stored in the oocyte are gradually degraded and transcription …

Aneuploidies are prevalent in the human embryo and impair proper development, leading to
cell cycle arrest. Recent advances in imaging and molecular and genetic analyses are …

Retrotransposons are “copy-and-paste” insertional mutagens that substantially contribute to
mammalian genome content. Retrotransposons often carry long terminal repeats (LTRs) for …

Although parental genomes undergo extensive epigenetic reprogramming to be equalized
after fertilization, whether they play different roles in human zygotic genome activation (ZGA) …

Conventional dogma presumes that protamine-mediated DNA compaction in sperm is
achieved by electrostatic interactions between DNA and the arginine-rich core of …

It remains poorly understood about the regulation of gene and transposon transcription
during human early embryogenesis. Here, we report that broad H3K27ac domains are …

The oocyte-to-embryo transition (OET) arguably initiates with formation of a primordial
follicle and culminates with reprogramming of gene expression during the course of zygotic …