Somatic cell nuclear transfer (SCNT) enables cloning of differentiated cells by
reprogramming their nuclei to a totipotent state. However, successful full-term development …

The zygotic genome is transcriptionally silent immediately after fertilization. In mice, initial
activation of the zygotic genome occurs in the middle of the one-cell stage. At the mid-to-late …

Preimplantation embryos experience profound resetting of epigenetic information inherited
from the gametes. Genome-wide analysis at single-base resolution has shown similarities …

Single‐cell RNA sequencing (scRNA‐seq) has emerged as a powerful tool for investigating
cell states and functions at the single‐cell level. It has greatly revolutionized transcriptomic …

The generation of human sensory neurons by directed differentiation of pluripotent stem
cells opens new opportunities for investigating the biology of pain. The inability to generate …

Interspecies blastocyst complementation enables organ-specific enrichment of xenogeneic
pluripotent stem cell (PSC) derivatives, which raises an intriguing possibility to generate …

Nucleosome-to-protamine exchange during mammalian spermiogenesis is essential for
compaction and protection of paternal DNA. It is interesting that, depending on the species …

In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which …

Sea anemones have been understudied as a source of peptide and protein toxins, with
relatively few examined as a source of new pharmacological tools or therapeutic leads. This …

The understanding of human biology and how it relates to that of other species represents
an ancient quest. Limited access to human material, particularly during early development …