Cells are the basic building blocks of organisms and each cell is unique. Single-cell RNA
sequencing has emerged as an indispensable tool to dissect the cellular heterogeneity and …

Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of
transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB …

Photo-assisted biofuel cell-based self-powered biosensors (PBFC-SPBs) possess the
advantages of no need for external power supply, ease of sensing design, and simple …

Human cleavage-stage embryos frequently acquire chromosomal aneuploidies during
mitosis due to unknown mechanisms. Here, we show that S phase at the 1-cell stage shows …

It is challenging to derive totipotent stem cells in vitro that functionally and molecularly
resemble cells from totipotent embryos. Here, we report that a chemical cocktail enables the …

Naive pluripotency is manifest in the preimplantation mammalian embryo. Here we
determine transcriptome dynamics of mouse development from the eight-cell stage to …

Single-cell genomics and single-cell transcriptomics have emerged as powerful tools to
study the biology of single cells at a genome-wide scale. However, a major challenge is to …

Effective cancer treatment has been precluded by the presence of various forms of
intratumoral complexity that drive treatment resistance and metastasis. Recent single-cell …

The major and essential objective of pre-implantation development is to establish embryonic
and extra-embryonic cell fates. To address when and how this fundamental process is …

Cellular specialization is particularly prominent in mammalian nervous systems, which are
composed of millions to billions of neurons that appear in thousands of different'flavors' and …