Abstract Facioscapulohumeral dystrophy (FSHD; MIM 158900, MIM 158901) is caused by
misexpression of the DUX4 transcription factor in skeletal muscle. Animal models of FSHD …

Single-cell RNASeq (scRNASeq) has emerged as a powerful method for quantifying the
transcriptome of individual cells. However, the data from scRNASeq experiments is often …

A major challenge in developmental biology is to understand the genetic and cellular
processes/programs driving organ formation and differentiation of the diverse cell types that …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

The emergence of form and function during mammalian embryogenesis is a complex
process that involves multiple regulatory levels. The foundations of the body plan are laid …

Reconstruction of the molecular pathways controlling organ development has been
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …

Abstract Poly (A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in
the oocyte-to-embryo transition (OET). Nothing is known about poly (A) tail dynamics during …

How the chromatin regulatory landscape in the inner cell mass cells is established from
differentially packaged sperm and egg genomes during preimplantation development is …

The ability to quantify cellular heterogeneity is a major advantage of single-cell
technologies. However, statistical methods often treat cellular heterogeneity as a nuisance …

About half of the human genome consists of highly repetitive elements, most of which are
considered dispensable for human life. Here, we report that repetitive elements originating …