Transcriptional control requires epigenetic changes directed by mitochondrial tricarboxylic
acid (TCA) cycle metabolites. In the mouse embryo, global epigenetic changes occur during …

Background Single-cell transcriptome and single-cell methylome technologies have become
powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide …

Conventional gene expression studies analyze multiple cells simultaneously or single cells,
for which the exact in vivo or in situ position is unknown. Although cellular heterogeneity can …

Single-cell profiling techniques create opportunities to delineate cell fate progression in
mammalian development. Recent studies have provided transcriptome data from human pre …

Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …

Single-cell RNA-sequencing methods are now robust and economically practical and are
becoming a powerful tool for high-throughput, high-resolution transcriptomic analysis of cell …

Reprogramming of H3K9me3-dependent heterochromatin is required for early development.
How H3K9me3 is involved in early human development remains, however, largely unclear …

The advent of large-scale microbiome studies affords newfound analytical opportunities to
understand how these communities of microbes operate and relate to their environment …

Motivation Most genomes contain thousands of genes, but for most functional responses,
only a subset of those genes are relevant. To facilitate many single-cell RNASeq …

Advances in whole-genome and whole-transcriptome amplification have permitted the
sequencing of the minute amounts of DNA and RNA present in a single cell, offering a …