Effective approaches to neuropsychiatric disorders require detailed understanding of the
cellular composition and circuitry of the complex mammalian brain. Here, we present a …

In recent years, more and more single-cell technologies have been developed. A vast
amount of single-cell omics data has been generated by large projects, such as the Human …

It remains an open question when and how the first cell fate decision is made in mammals.
Using deep single-cell RNA-seq of matched sister blastomeres, we report highly …

In the interphase of the cell cycle, chromatin is arranged in a hierarchical structure within the
nucleus,, which has an important role in regulating gene expression,,–. However, the …

Embryonic gene expression intricately reflects anatomical context, developmental stage,
and cell type. To address whether the precise spatial origins of cardiac cells can be deduced …

It remains poorly understood about the regulation of gene and transposon transcription
during human early embryogenesis. Here, we report that broad H3K27ac domains are …

The scarcity of tissue-specific stem cells and the complexity of their surrounding environment
have made molecular characterization of these cells particularly challenging. Through single …

The molecular regulation of zygotic genome activation (ZGA) in mammals remains an
exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C …

During maternal-to-embryonic transition control of embryonic development gradually
switches from maternal RNAs and proteins stored in the oocyte to gene products generated …

During early mammalian embryogenesis, changes in cell growth and proliferation depend
on strict genetic and metabolic instructions. However, our understanding of metabolic …