Retrotransposons mediate gene regulation in important developmental and pathological
processes. Here, we characterized the transient retrotransposon induction during …

Sex chromosome dosage compensation is essential in most metazoans, but the
developmental timing and underlying mechanisms vary significantly, even among placental …

Following fertilization, gametes undergo epigenetic reprogramming in order to revert to a
totipotent state. How embryonic cells subsequently acquire their fate and the role of …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Genetic changes and environmental differences result in cellular heterogeneity among
cancer cells within the same tumor, thereby complicating treatment outcomes. Recent …

Differentiated somatic cells can be reprogrammed into totipotent embryos through somatic
cell nuclear transfer. However, most cloned embryos arrest at early stages and the …

Mouse embryonic stem cells (ESCs) sporadically express preimplantation two-cell-stage
(2C) transcripts, including MERVL endogenous retrovirus and Zscan4 cluster genes. Such …

The ovary is perhaps the most dynamic organ in the human body, only rivaled by the uterus.
The molecular mechanisms that regulate follicular growth and regression, ensuring ovarian …

Concerted examination of multiple collections of single-cell RNA sequencing (RNA-seq)
data promises further biological insights that cannot be uncovered with individual datasets …

Pre-implantation embryo development is an intricate and precisely regulated process
orchestrated by maternally inherited proteins and newly synthesized proteins following …